Advances and Challenges in RSV Vaccine Development: Pathways toward Global Protection

Haoxiang Wang

2025

Abstract

Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infection in infants and young children worldwide. Recent breakthroughs in molecular biology and vaccine technology have shifted prevention efforts from antivirals to targeted immunization, including protein and nucleic acid– based platforms. Currently approved recombinant protein vaccines-Abrysvo (for pregnant women) and Arexvy (for older adults)-demonstrate strong safety and efficacy profiles. However, developing vaccines for neonates remains challenging due to their immature immune systems and variable responses. This review summarizes the evolution of RSV vaccine design, underlying immunological mechanisms, and results from pivotal clinical trials. We highlight ongoing strategies to overcome neonatal immunogenicity hurdles and outline future directions for creating safe, broad-spectrum RSV vaccines suitable for all age groups.

Paper Citation

in Harvard Style

Wang H. (2025). Advances and Challenges in RSV Vaccine Development: Pathways toward Global Protection. In Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS; ISBN 978-989-758-789-4, SciTePress, pages 324-329. DOI: 10.5220/0014487800004933

in Bibtex Style

@conference{befs25,
author={Haoxiang Wang},
title={Advances and Challenges in RSV Vaccine Development: Pathways toward Global Protection},
booktitle={Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS},
year={2025},
pages={324-329},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0014487800004933},
isbn={978-989-758-789-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS
TI - Advances and Challenges in RSV Vaccine Development: Pathways toward Global Protection
SN - 978-989-758-789-4
AU - Wang H.
PY - 2025
SP - 324
EP - 329
DO - 10.5220/0014487800004933
PB - SciTePress