Exploring the Connection between CRISPR-Cas9 and Alzheimer's Disease Therapy

Xinyu Lin

2025

Abstract

Alzheimer's disease (AD), which is a neurodegenerative disorder, has a pathophysiology that remains unclear, and there is a lack of effective treatments for this condition. The CRISPR/Cas9 gene - editing technique shows great promise in treating AD. It can target genes like APP, BACE1, and APOE to reduce Aβ production. However, its clinical application faces challenges. Delivery methods, including biological systems, local injections, and viral/non - viral vectors, have limitations such as poor blood - brain barrier penetration, invasiveness, and immunogenicity. Animal models created by CRISPR/Cas9 are beneficial for researching the pathogenesis of AD. However, issues such as off - target effects, long - term safety, and ethical concerns still need to be resolved. In upcoming research, it is essential to focus on improving delivery systems and gene - editing approaches. Only in this way can the potential of CRISPR/Cas9 in the treatment of AD be fully realized.

Paper Citation

in Harvard Style

Lin X. (2025). Exploring the Connection between CRISPR-Cas9 and Alzheimer's Disease Therapy. In Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS; ISBN 978-989-758-789-4, SciTePress, pages 295-300. DOI: 10.5220/0014487000004933

in Bibtex Style

@conference{befs25,
author={Xinyu Lin},
title={Exploring the Connection between CRISPR-Cas9 and Alzheimer's Disease Therapy},
booktitle={Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS},
year={2025},
pages={295-300},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0014487000004933},
isbn={978-989-758-789-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS
TI - Exploring the Connection between CRISPR-Cas9 and Alzheimer's Disease Therapy
SN - 978-989-758-789-4
AU - Lin X.
PY - 2025
SP - 295
EP - 300
DO - 10.5220/0014487000004933
PB - SciTePress