Research Progress on the Role and Potential of N6-Methyladenosine in Gastric Cancer Treatment

Ye He

2025

Abstract

N6-methyladenosine (m6A) is the most prevalent RNA modification, playing a crucial role in RNA metabolism, including stability, splicing, translation, and degradation. Dysregulation of m6A is involved in gastric cancer (GC), affecting tumorigenesis, epithelial-mesenchymal transition(EMT), and chemotherapy resistance. In GC, m6A modification promotes oncogene translation and alters non-coding RNA (ncRNA) interactions, contributing to tumor proliferation, invasion, and therapy resistance. Overexpression of METTL3 and YTHDF1 enhances m6A methylation which leads to MYC upregulation and EMT progression, while FTO depletion stabilizes E-cadherin, suppressing tumor metastasis. Moreover, ncRNAs are transcriptional modulators significantly affected by m6A modifications, influencing tumor growth and drug resistance. Additionally, m6A regulates various forms of programmed cell death, including pyroptosis, ferroptosis, autophagy, and cuproptosis, which indicates potential therapeutic target. Emerging strategies, such as CRISPR-Cas9 and epigenetic modulation, offer new approaches for targeting m6A-related pathways. Combining m6A-targeted therapies with conventional treatments may enhance GC outcomes, improving patient quality of life and survival.

Paper Citation

in Harvard Style

He Y. (2025). Research Progress on the Role and Potential of N6-Methyladenosine in Gastric Cancer Treatment. In Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS; ISBN 978-989-758-789-4, SciTePress, pages 267-272. DOI: 10.5220/0014486300004933

in Bibtex Style

@conference{befs25,
author={Ye He},
title={Research Progress on the Role and Potential of N6-Methyladenosine in Gastric Cancer Treatment},
booktitle={Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS},
year={2025},
pages={267-272},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0014486300004933},
isbn={978-989-758-789-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS
TI - Research Progress on the Role and Potential of N6-Methyladenosine in Gastric Cancer Treatment
SN - 978-989-758-789-4
AU - He Y.
PY - 2025
SP - 267
EP - 272
DO - 10.5220/0014486300004933
PB - SciTePress