Genetic Risk Factors for Alzheimer’s Disease

Linlu Dai

2025

Abstract

Amyloid-Beta plaques and neurofibrillary tangles are the main causes of Alzheimer's disease (AD), a brain condition that results in memory loss and cognitive impairment. Both environmental and genetic factors contribute to it. While the APOE ε4 gene increases the risk of late-onset AD, rare mutations in PSEN1, PSEN2, and APP cause early-onset AD. Other genes, including TREM2, CLU, and PICALM, have been linked to AD by genome-wide association studies (GWAS). Genetic risk is assessed using Polygenic Risk Scores (PRS). However, environmental and lifestyle variables also play a significant role in the development of illness.

Paper Citation

in Harvard Style

Dai L. (2025). Genetic Risk Factors for Alzheimer’s Disease. In Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS; ISBN 978-989-758-789-4, SciTePress, pages 134-143. DOI: 10.5220/0014436700004933

in Bibtex Style

@conference{befs25,
author={Linlu Dai},
title={Genetic Risk Factors for Alzheimer’s Disease},
booktitle={Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS},
year={2025},
pages={134-143},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0014436700004933},
isbn={978-989-758-789-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS
TI - Genetic Risk Factors for Alzheimer’s Disease
SN - 978-989-758-789-4
AU - Dai L.
PY - 2025
SP - 134
EP - 143
DO - 10.5220/0014436700004933
PB - SciTePress