Research Progress of Ebola Live Vector Vaccine

Jiaqi Mi

2025

Abstract

Ebola virus is a highly lethal virus belonging to the Filoviridae family. The virus is mainly transmitted through the patient's body fluids and may cause Ebola hemorrhagic fever, with a mortality rate of up to 25% to 90%. The early manifestations of Ebola hemorrhagic fever commonly involve fever and muscle pain, followed by severe symptoms such as vomiting, diarrhea, internal and external bleeding, which may eventually lead to organ failure and death. Live vector vaccines created an innovative class of immunization. It employs attenuated viruses or bacteria as delivery vehicles. These carriers transport specific pathogen antigens into host cells, thereby stimulating the body's immune system to generate a protective response. With the advancement of genetic engineering, this vaccine has been widely used in the prevention and treatment of various diseases. Among them, the Ebola vaccine (Ervebo) has been widely used in many African countries. This article reviews the current status and progress of Ebola live vector vaccines by combing and analyzing relevant domestic and foreign literature. Focuses on the therapeutic mechanism of the Ebola vaccine and the drug production process. By comparing drugs currently on the market or in the clinical stage, this article found that there are some difficulties in the current Ebola vaccine research field, mainly in terms of vaccine specificity and storage technology. In the end, this paper comprehensively reviews the existing research, points out the shortcomings of current research, and predicts future development trends, aiming to provide a reference for researchers for further exploration in the field of Ebola live vector vaccines and provide some ideas and suggestions for subsequent research.

Paper Citation

in Harvard Style

Mi J. (2025). Research Progress of Ebola Live Vector Vaccine. In Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS; ISBN 978-989-758-789-4, SciTePress, pages 128-133. DOI: 10.5220/0014436600004933

in Bibtex Style

@conference{befs25,
author={Jiaqi Mi},
title={Research Progress of Ebola Live Vector Vaccine},
booktitle={Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS},
year={2025},
pages={128-133},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0014436600004933},
isbn={978-989-758-789-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS
TI - Research Progress of Ebola Live Vector Vaccine
SN - 978-989-758-789-4
AU - Mi J.
PY - 2025
SP - 128
EP - 133
DO - 10.5220/0014436600004933
PB - SciTePress