The Role of Lipid Metabolism in Cancer Progression: Molecular Mechanisms and Therapeutic Strategies

Yuchen Han

2025

Abstract

Cancer cells undergo significant metabolic reprogramming to support their rapid proliferation, survival, and resistance to therapy. One key metabolic shift observed in tumors is the alteration in lipid metabolism, particularly in fatty acid oxidation (FAO), fatty acid synthesis (FAS), lipid uptake, and lipid storage. Unlike normal cells, cancer cells rely on FAO to sustain energy production under metabolic stress while also upregulating lipid synthesis and up-take to fuel tumor growth and metastasis. This study explores how targeting FAO, FAS, and li-pid uptake can provide new therapeutic opportunities. The article will discuss FAO inhibitors (Etomoxir, ST1326, Perhexiline), FASN inhibitors (TVB-2640, C75, Orlistat), and lipid uptake blockers (CD36 and FABP inhibitors) as emerging anti-cancer strategies. Additionally, it will analyze how metabolic plasticity allows tumors to bypass these treatments, emphasizing the need for combination therapies and personalized approaches. By addressing these aspects, the article aims to provide insights of lipid metabolism in cancer progression, the latest therapeutic advances, and the challenges of translating these strategies into clinical applications.

Paper Citation

in Harvard Style

Han Y. (2025). The Role of Lipid Metabolism in Cancer Progression: Molecular Mechanisms and Therapeutic Strategies. In Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS; ISBN 978-989-758-789-4, SciTePress, pages 117-123. DOI: 10.5220/0014431600004933

in Bibtex Style

@conference{befs25,
author={Yuchen Han},
title={The Role of Lipid Metabolism in Cancer Progression: Molecular Mechanisms and Therapeutic Strategies},
booktitle={Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS},
year={2025},
pages={117-123},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0014431600004933},
isbn={978-989-758-789-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS
TI - The Role of Lipid Metabolism in Cancer Progression: Molecular Mechanisms and Therapeutic Strategies
SN - 978-989-758-789-4
AU - Han Y.
PY - 2025
SP - 117
EP - 123
DO - 10.5220/0014431600004933
PB - SciTePress