Advances in Chiral Construction and Biochemical Applications of Chiral Gold Nanoparticles

Jinpeng Huang, Haowen Zhang

2025

Abstract

Chiral gold nanoparticles (AuNPs) leverage nanoscale geometric asymmetry to amplify chirality-encoded functions, bridging molecular stereochemistry with plasmonic material properties. Their chirality arises from helical surface nanostructures or ligand-induced asymmetry, enabling strong chiroptical responses via plasmon-exciton coupling and circular dichroism enhancement. Bottom-up synthesis strategies-such as chiral ligand templating (e.g., cysteine, peptides) directing atomic lattice distortion, enantioselective growth on chiral seeds, and plasmon-guided self-assembly of achiral units into supramolecular helices-allow precise control over 3D chiral geometries. These architectures interact selectively with biomolecules through stereocomplementary interfaces, enhancing enantiomer discrimination (e.g., drug detection at ppm levels) and enabling chirality-dependent cellular uptake. In photomedicine, chiral AuNPs exploit plasmon-enhanced circularly polarized light absorption for targeted photothermal therapy and ROS generation, while their asymmetric catalytic sites promote stereoselective synthesis. However, challenges include weak interfacial chirality transfer, limited dynamic reconfiguration of chiral fields, and signal attenuation in biological environments. Advancing in situ chiral monitoring (e.g., chiral SERS) and adaptive chirality modulation via stimuli-responsive ligands could unlock applications like real-time chiral biomarker tracking and logic-gated nanomedicine. Integrating nanoscale chirality with quantum plasmonics further positions chiral AuNPs as multifunctional platforms for beyond-molecular stereochemical engineering.

Paper Citation

in Harvard Style

Huang J. and Zhang H. (2025). Advances in Chiral Construction and Biochemical Applications of Chiral Gold Nanoparticles. In Proceedings of the 2nd International Conference on Innovations in Applied Mathematics, Physics, and Astronomy - Volume 1: IAMPA; ISBN 978-989-758-774-0, SciTePress, pages 476-481. DOI: 10.5220/0013827800004708

in Bibtex Style

@conference{iampa25,
author={Jinpeng Huang and Haowen Zhang},
title={Advances in Chiral Construction and Biochemical Applications of Chiral Gold Nanoparticles},
booktitle={Proceedings of the 2nd International Conference on Innovations in Applied Mathematics, Physics, and Astronomy - Volume 1: IAMPA},
year={2025},
pages={476-481},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0013827800004708},
isbn={978-989-758-774-0},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd International Conference on Innovations in Applied Mathematics, Physics, and Astronomy - Volume 1: IAMPA
TI - Advances in Chiral Construction and Biochemical Applications of Chiral Gold Nanoparticles
SN - 978-989-758-774-0
AU - Huang J.
AU - Zhang H.
PY - 2025
SP - 476
EP - 481
DO - 10.5220/0013827800004708
PB - SciTePress