Exploring the Bioactive Metabolites with Anti-Malarial Properties Derived from Endophytic Microbial Resources Indigenous to Indonesia

Elsera Br Tarigan, Partomuan Simanjuntak, Dwinna Rahmi, Andria Agusta, Praptiwi, Erwahyuni Endang Prabandari, Danang Waluyo, Muhammad Ilyas

2024

Abstract

Malaria, caused by parasite infection, is still difficult to cure due to partial treatment resistance. This emphasizes the need for innovative molecules with different modes of action, particularly those derived from unconventional sources such as endophytic microbes. This study investigates endophytes from medicinal plants in order to find possible antimalarial drugs that target Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH). Endophytes were associated to Mitragyna speciosa, Zingiberaceae, Uncaria gambir, and others, yielding 586 species. Screening using a 96-well plate produced a z-factor of 0.92, indicating trustworthy findings. Hypomycetes (from Physalis angulata L.) and Fusarium sp. (from Hornstedtia scyphifera) showed considerable anti-malarial activity, suppressing PfDHODH by 51.53% and 66.37%, respectively. Metabolomic profiling using LC-HRMS demonstrated that Hypomycetes included bioactive substances such as uracil, kojic acid, and phloroglucinol, whereas Fusarium sp

Paper Citation

in Harvard Style

Tarigan E., Simanjuntak P., Rahmi D., Agusta A., Praptiwi., Prabandari E., Waluyo D. and Ilyas M. (2024). Exploring the Bioactive Metabolites with Anti-Malarial Properties Derived from Endophytic Microbial Resources Indigenous to Indonesia. In Proceedings of BRIN’s 2nd International Conference for Health Research - Volume 1: ICHR; ISBN 978-989-758-755-9, SciTePress, pages 47-53. DOI: 10.5220/0013554600004612

in Bibtex Style

@conference{ichr24,
author={Elsera Br Tarigan and Partomuan Simanjuntak and Dwinna Rahmi and Andria Agusta and Praptiwi and Erwahyuni Prabandari and Danang Waluyo and Muhammad Ilyas},
title={Exploring the Bioactive Metabolites with Anti-Malarial Properties Derived from Endophytic Microbial Resources Indigenous to Indonesia},
booktitle={Proceedings of BRIN’s 2nd International Conference for Health Research - Volume 1: ICHR},
year={2024},
pages={47-53},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0013554600004612},
isbn={978-989-758-755-9},
}

in EndNote Style

TY - CONF

JO - Proceedings of BRIN’s 2nd International Conference for Health Research - Volume 1: ICHR
TI - Exploring the Bioactive Metabolites with Anti-Malarial Properties Derived from Endophytic Microbial Resources Indigenous to Indonesia
SN - 978-989-758-755-9
AU - Tarigan E.
AU - Simanjuntak P.
AU - Rahmi D.
AU - Agusta A.
AU - Praptiwi.
AU - Prabandari E.
AU - Waluyo D.
AU - Ilyas M.
PY - 2024
SP - 47
EP - 53
DO - 10.5220/0013554600004612
PB - SciTePress