Genetic Aspects of Arterial Hypertension: How Gene Polymorphisms Determine the Risk of Developing Hypertension

Abidova Dilorom Ergashevna, Muhamedova Muyassar Gafurjanovna, Mullabayeva Guzal Uchkunona

2024

Abstract

Arterial hypertension (AH) is one of the leading causes of cardiovascular diseases and premature death. Recently, special attention has been paid to genetic markers that may predispose to the development of AH and its complications. The presented study, conducted with the participation of 392 people (100 without AH and 292 with AH), was focused on the analysis of genetic factors influencing the development of hypertension, myocardial hypertrophy and obesity. Genetic markers, such as polymorphisms of the AGTR1, AGTR2, AGT, ADD1, CYP11B2, NOS3 and GNB3 genes, were studied using PCR and other molecular methods. The results showed that the AGTR1 and AGTR2 genes did not have statistically significant differences between the groups. However, the ADD1 gene was associated with a family history of hypertension, and the CYP11B2 mutation was associated with obesity, as confirmed by the WC/HR indicator. The GNB3 gene showed a direct relationship with the presence of left ventricular hypertrophy and the WC/HR level. These data confirm the importance of genetic testing for assessing the risks of developing hypertension and its complications, as well as the need for further research to develop personalized approaches to the treatment and prevention of hypertension.

Paper Citation

in Harvard Style

Ergashevna A., Gafurjanovna M. and Uchkunona M. (2024). Genetic Aspects of Arterial Hypertension: How Gene Polymorphisms Determine the Risk of Developing Hypertension. In Proceedings of the 4th International Conference on Humanities Education, Law, and Social Science - Volume 1: ICHELS; ISBN 978-989-758-752-8, SciTePress, pages 762-769. DOI: 10.5220/0013424600004654

in Bibtex Style

@conference{ichels24,
author={Abidova Ergashevna and Muhamedova Gafurjanovna and Mullabayeva Uchkunona},
title={Genetic Aspects of Arterial Hypertension: How Gene Polymorphisms Determine the Risk of Developing Hypertension},
booktitle={Proceedings of the 4th International Conference on Humanities Education, Law, and Social Science - Volume 1: ICHELS},
year={2024},
pages={762-769},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0013424600004654},
isbn={978-989-758-752-8},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Humanities Education, Law, and Social Science - Volume 1: ICHELS
TI - Genetic Aspects of Arterial Hypertension: How Gene Polymorphisms Determine the Risk of Developing Hypertension
SN - 978-989-758-752-8
AU - Ergashevna A.
AU - Gafurjanovna M.
AU - Uchkunona M.
PY - 2024
SP - 762
EP - 769
DO - 10.5220/0013424600004654
PB - SciTePress