Synthesis, Characterization, and Antiproliferation Activity Test of Dibutyltin(IV)di-2-Hydroxybenzoate and Dibutyltin(IV)di-3- Hydroxybenzoate Against Cervical Cancer Line Hela

Sutopo Hadi, Hendig Winarno, Ermin Katrin Winarno, Susanto, Mitha Nurmaya Angely, Amelia Mareta, Khairun Nisa Berawi, Tati Suhartati

2023

Abstract

Due to the various side effects of conventional cancer treatment therapy, efforts to find anticancer agents with minimum side effects are in great demand. One of them is the synthesis of organotin (IV) hydroxybenzoate derivatives. Two organotin (IV) compounds, namely dibutyltin (IV) 2-hydroxybenzoate and dibutyltin (IV) di-3-hydroxybenzoate, have been successfully synthesized. The products were obtained by reacting the dibutyltin (IV) oxide with 2-hydroxybenzoic acid and 3-hydroxybenzoic acid. The compounds synthesized were fully characterized by UV-Vis, FT-IR, and NMR spectroscopies and microelemental analyzer to see the purity of the compounds. The antiproliferative activity of compounds have been tested against the HeLa cancer cell line. The results of the antiproliferation test showed that the compound dibutyltin (IV) 2-hydroxybenzoate had better antiproliferation activity than the compound dibutyltin (IV) 3-hydroxybenzoate and showed high selectivity.

Paper Citation

in Harvard Style

Hadi S., Winarno H., Winarno E., Susanto., Angely M., Mareta A., Berawi K. and Suhartati T. (2023). Synthesis, Characterization, and Antiproliferation Activity Test of Dibutyltin(IV)di-2-Hydroxybenzoate and Dibutyltin(IV)di-3- Hydroxybenzoate Against Cervical Cancer Line Hela. In Proceedings of the 1st International Conference on Medical Science and Health - Volume 1: ICOMESH; ISBN 978-989-758-740-5, SciTePress, pages 228-233. DOI: 10.5220/0013668400003873

in Bibtex Style

@conference{icomesh23,
author={Sutopo Hadi and Hendig Winarno and Ermin Katrin Winarno and Susanto and Mitha Nurmaya Angely and Amelia Mareta and Khairun Nisa Berawi and Tati Suhartati},
title={Synthesis, Characterization, and Antiproliferation Activity Test of Dibutyltin(IV)di-2-Hydroxybenzoate and Dibutyltin(IV)di-3- Hydroxybenzoate Against Cervical Cancer Line Hela},
booktitle={Proceedings of the 1st International Conference on Medical Science and Health - Volume 1: ICOMESH},
year={2023},
pages={228-233},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0013668400003873},
isbn={978-989-758-740-5},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Medical Science and Health - Volume 1: ICOMESH
TI - Synthesis, Characterization, and Antiproliferation Activity Test of Dibutyltin(IV)di-2-Hydroxybenzoate and Dibutyltin(IV)di-3- Hydroxybenzoate Against Cervical Cancer Line Hela
SN - 978-989-758-740-5
AU - Hadi S.
AU - Winarno H.
AU - Winarno E.
AU - Susanto.
AU - Angely M.
AU - Mareta A.
AU - Berawi K.
AU - Suhartati T.
PY - 2023
SP - 228
EP - 233
DO - 10.5220/0013668400003873
PB - SciTePress