The Effect of Rhizophora apiculata Bark Ethanol Extract on Burns Healing of Rattus norvegicus Sprague Dawley Strain

Syazili Mustofa, Delisa Mutiara Nabila, Evi Kurniawaty

2023

Abstract

This study aimed to evaluate the ability of an ethanolic extract of Rhizophora apiculata bark to treat burn wounds in rats. Second-degree burn wounds were induced in five groups of six rats each, and topical treatment was done daily for 26 days. Group KN and K+ received aqua bidestilata and bioplacenton® (containing placenta extract 10% and neomycin sulfate 5%) as a control and reference standard, and group P1, P2 and P3 were given ethanolic Rhizophora apiculata bark extract of 20%, 30% and 40% respectively. The observing burn wounds for ± 26 days were enrolled for evaluating the effects on the burn healing phase, burn area reduction, and burn healing time. The area of burn wounds in the groups of rats given the extract began to shrink more quickly on the 15th day of observation. The One-way ANOVA test revealed p=0.001, and the LSD Post Hoc test revealed p < 0.05, indicating a significant difference in the area of burns on day 15 for all treatment groups. The healed wounds in extracts-treated rats were faster and had better wound healing time. Wound contractions were relatively better in extract groups. In conclusion, the Rhizhopra apiculata bark ethanolic extract positively affected wound burn healing activity.

Paper Citation

in Harvard Style

Mustofa S., Nabila D. and Kurniawaty E. (2023). The Effect of Rhizophora apiculata Bark Ethanol Extract on Burns Healing of Rattus norvegicus Sprague Dawley Strain. In Proceedings of the 1st International Conference on Medical Science and Health - Volume 1: ICOMESH; ISBN 978-989-758-740-5, SciTePress, pages 223-227. DOI: 10.5220/0013668300003873

in Bibtex Style

@conference{icomesh23,
author={Syazili Mustofa and Delisa Mutiara Nabila and Evi Kurniawaty},
title={The Effect of Rhizophora apiculata Bark Ethanol Extract on Burns Healing of Rattus norvegicus Sprague Dawley Strain},
booktitle={Proceedings of the 1st International Conference on Medical Science and Health - Volume 1: ICOMESH},
year={2023},
pages={223-227},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0013668300003873},
isbn={978-989-758-740-5},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Medical Science and Health - Volume 1: ICOMESH
TI - The Effect of Rhizophora apiculata Bark Ethanol Extract on Burns Healing of Rattus norvegicus Sprague Dawley Strain
SN - 978-989-758-740-5
AU - Mustofa S.
AU - Nabila D.
AU - Kurniawaty E.
PY - 2023
SP - 223
EP - 227
DO - 10.5220/0013668300003873
PB - SciTePress