Curcuma Extract as an Alternative and Safety Pain Reliever for Geriatric with Knee Osteoarthritis: A Systematic Review and Meta Analysis

Mohammad Satrio Wicaksono, Clarissa Aulia Pravitha, Hamdi Ramadhan Daulay

2023

Abstract

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) as pain relievers for osteoarthritis patients that have several side effects in long-term treatment. Meanwhile based on Global Burden of Disease 2019, about 528 million people have osteoarthritis, which 73% are geriatric patients. Therefore, this study aimed to evaluate the efficacy and safety of curcuma extract compared to NSAIDs in the treatment of geriatric patients with knee osteoarthritis. This study was made with a systematic literature search method from three databases, such as PubMed, ScienceDirect, and ProQuest. Inclusion criteria included experimental randomized control trials and discussed related topics. Mean difference and standard deviation were displayed as the results. With an I2 value of less than 40%, a fixed-effect model was suggested. For randomized trials, the Cochrane risk-of-bias tool was used to evaluate the risk of bias (RoB 2). There were a total of 671 participants in five randomized control trial trials. The pooled mean difference of the VAS score decreased significantly, with a 95% confidence interval (CI) of (-2.97) - (-0.92), P=0.0002, and an I2 of 99%. The I2 data for the KOOS index indicates 0%, and the pooled mean difference is a significant 2.82 [95% CI: 1.48-4.16, P<0.0001]. NSAID-like medications and curcuma extracts are similar in terms of effectiveness and safety.

Paper Citation

in Harvard Style

Wicaksono M., Pravitha C. and Daulay H. (2023). Curcuma Extract as an Alternative and Safety Pain Reliever for Geriatric with Knee Osteoarthritis: A Systematic Review and Meta Analysis. In Proceedings of the 1st International Conference on Medical Science and Health - Volume 1: ICOMESH; ISBN 978-989-758-740-5, SciTePress, pages 69-77. DOI: 10.5220/0013666200003873

in Bibtex Style

@conference{icomesh23,
author={Mohammad Satrio Wicaksono and Clarissa Aulia Pravitha and Hamdi Ramadhan Daulay},
title={Curcuma Extract as an Alternative and Safety Pain Reliever for Geriatric with Knee Osteoarthritis: A Systematic Review and Meta Analysis},
booktitle={Proceedings of the 1st International Conference on Medical Science and Health - Volume 1: ICOMESH},
year={2023},
pages={69-77},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0013666200003873},
isbn={978-989-758-740-5},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Medical Science and Health - Volume 1: ICOMESH
TI - Curcuma Extract as an Alternative and Safety Pain Reliever for Geriatric with Knee Osteoarthritis: A Systematic Review and Meta Analysis
SN - 978-989-758-740-5
AU - Wicaksono M.
AU - Pravitha C.
AU - Daulay H.
PY - 2023
SP - 69
EP - 77
DO - 10.5220/0013666200003873
PB - SciTePress