In Vitro Anticancer Potential of Avicennia marina Leave Extract and Taurin on HeLa Cell Line: An Alternative Approach of Anticancer

Silvia Andriani, Endang Linirin Widiastuti, Evi Kurniawaty, Suharyani, Iffa Afiqa Khairani, Dea Putri Andeska

2023

Abstract

The pharmacological activities of Avicennia marina tree leaves, often known as api, have been scientifically proven to include anti-inflammatory, analgesic, and toxicological effects. The Avicennia marina plant is thought to have anticancer qualities since it contains high levels of flavonoids, tannins, saponins, and alkaloids. Taurine's organic acids has antioxidant and anticancer properties, alongside mangrove plants. Cancer is caused by excessive cell growth, which damages surrounding cells and tissues. Currently, cervical cancer is the second most common cause of mortality among women globally. The MTT technique (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide) on HeLa cervical cancer cell cultures showed that leaf extract and taurine effectively inhibited cancer growth. The findings indicated that the leaf extract of api-api and taurine had cytotoxic properties, with IC50 values of 206 ppm, 122 ppm, and 603 ppm, respectively. In contrast, the antiproliferation test demonstrated that the api-api leaf extract and taurine exhibited a longer period of cell division compared to the control cells, with doubling times of 72 and 19 hours, respectively. The utilization of api-api leaf extract and taurine exhibited a deleterious impact on HeLa cells as compared to untreated cells (control cells). Treatment also inhibited cell proliferation, as shown by the longer doubling time of treated cells compared to control cells.

Paper Citation

in Harvard Style

Andriani S., Widiastuti E., Kurniawaty E., Suharyani., Khairani I. and Andeska D. (2023). In Vitro Anticancer Potential of Avicennia marina Leave Extract and Taurin on HeLa Cell Line: An Alternative Approach of Anticancer. In Proceedings of the 1st International Conference on Medical Science and Health - Volume 1: ICOMESH; ISBN 978-989-758-740-5, SciTePress, pages 25-31. DOI: 10.5220/0013110000003873

in Bibtex Style

@conference{icomesh23,
author={Silvia Andriani and Endang Linirin Widiastuti and Evi Kurniawaty and Suharyani and Iffa Afiqa Khairani and Dea Putri Andeska},
title={In Vitro Anticancer Potential of Avicennia marina Leave Extract and Taurin on HeLa Cell Line: An Alternative Approach of Anticancer},
booktitle={Proceedings of the 1st International Conference on Medical Science and Health - Volume 1: ICOMESH},
year={2023},
pages={25-31},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0013110000003873},
isbn={978-989-758-740-5},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Medical Science and Health - Volume 1: ICOMESH
TI - In Vitro Anticancer Potential of Avicennia marina Leave Extract and Taurin on HeLa Cell Line: An Alternative Approach of Anticancer
SN - 978-989-758-740-5
AU - Andriani S.
AU - Widiastuti E.
AU - Kurniawaty E.
AU - Suharyani.
AU - Khairani I.
AU - Andeska D.
PY - 2023
SP - 25
EP - 31
DO - 10.5220/0013110000003873
PB - SciTePress