Transcriptional Changes of Genes Linked to Alzheimer’s Disease

Wanning He

2022

Abstract

Alzheimer’s disease is a pogressive neurodegenerative disease that constitutes most cases of dementia. This study aims to converge existing data from GWAS studies and bulk RNA-Seq from patients with and without Alzheimer’s disease to prioritize genes involved in the disease pathology. For this study, I examine existing bulk RNA-Seq datasets from patients with and without Alzheimer’s disease [GSE159699], focusing on genes previously identified as links to late-onset Alzheimer’s disease in GWAS studies. I confirmed my results with a publicly available AD transcriptomics consensus tool published by the Swarup lab. In my analysis, I identified shared gene expression differences in STAG3L5P, MEF2C, MS4A6A, PILRA and CASS4 between Alzheimer’s disease and control patients across several datasets. These genes were previously linked to late-onset Alzheimer’s disease. Further investigation should explore how their mutations and gene expression differences contribute to the mechanisms underlying Alzheimer’s disease.

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Paper Citation


in Harvard Style

He W. (2022). Transcriptional Changes of Genes Linked to Alzheimer’s Disease. In Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB, ISBN 978-989-758-595-1, pages 1112-1118. DOI: 10.5220/0011378300003443


in Bibtex Style

@conference{icbeb22,
author={Wanning He},
title={Transcriptional Changes of Genes Linked to Alzheimer’s Disease},
booktitle={Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,},
year={2022},
pages={1112-1118},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011378300003443},
isbn={978-989-758-595-1},
}


in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,
TI - Transcriptional Changes of Genes Linked to Alzheimer’s Disease
SN - 978-989-758-595-1
AU - He W.
PY - 2022
SP - 1112
EP - 1118
DO - 10.5220/0011378300003443