A Statistical Analysis of Chronic Liver Disease Diagnosis with Noninvasive Biomarkers

Pinyi Zhen

2022

Abstract

Chronic hepatitis C virus infection (CHC) can cause life-threatening liver diseases such as cirrhosis and fibrosis. This study aims to investigate how noninvasive serum biomarkers can aid in CHC infected liver disease diagnosis. Previous studies have researched various combinations of serum biomarkers. This study examines the diagnosing effect of a different combination of serum biomarkers on CHC patients. A multinomial logistics regression model is employed to make a secondary analysis of the HCV dataset. We use LASSO, stepwise regression, and ridge regression for model selection. Average accuracy, sensitivity, precision, and specificity are calculated to evaluate model performance. Our statistical analysis resulted in high accuracy and specificity. The average accuracy and sensitivity for predicting cirrhosis have both achieved 99%. The average specificity for predicting fibrosis has attained 95%. Our statistical analysis result implicates that future research on CHC diagnosis can analyze different combinations of serum biomarkers or even genetic markers.

Paper Citation

in Harvard Style

Zhen P. (2022). A Statistical Analysis of Chronic Liver Disease Diagnosis with Noninvasive Biomarkers. In Proceedings of the 1st International Conference on Health Big Data and Intelligent Healthcare - Volume 1: ICHIH, ISBN 978-989-758-596-8, pages 76-82. DOI: 10.5220/0011231300003438

in Bibtex Style

@conference{ichih22,
author={Pinyi Zhen},
title={A Statistical Analysis of Chronic Liver Disease Diagnosis with Noninvasive Biomarkers},
booktitle={Proceedings of the 1st International Conference on Health Big Data and Intelligent Healthcare - Volume 1: ICHIH,},
year={2022},
pages={76-82},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011231300003438},
isbn={978-989-758-596-8},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Health Big Data and Intelligent Healthcare - Volume 1: ICHIH,
TI - A Statistical Analysis of Chronic Liver Disease Diagnosis with Noninvasive Biomarkers
SN - 978-989-758-596-8
AU - Zhen P.
PY - 2022
SP - 76
EP - 82
DO - 10.5220/0011231300003438