H. Malberg, R. Bauernschmitt, T. Walther, A. Voss, Renaldo Faber, Holger Stepan, N. Wessel



Pre-eclampsia is a serious disorder with high morbidity and mortality occurring during pregnancy; 3%–5% of all pregnant women are affected. Although most pre-eclamptic patients show pathological uterine perfusion in the second trimester, this parameter has a positive predictive accuracy of only 30%, which makes it unsuitable for early, reliable prediction. The study is based on the hypothesis that alterations in cardiovascular regulatory behavior can be used to predict PE. Ninety-six pregnant women in whom Doppler investigation detected perfusion disorders of the uterine arteries were included in the study. Twentyfour of these pregnant women developed PE after the 30th week of gestation. During pregnancy, additional several non-invasive continuous blood pressure recordings were made over 30 min under resting conditions by means of a finger cuff. In the period between the 18th and 26th weeks of pregnancy, three special variability and baroreflex parameters were able to predict PE several weeks before clinical manifestation. Discriminant function analysis of these parameters was able to predict PE with a sensitivity and specificity of 87.5% and a positive predictive value of 70%. The combined clinical assessment of uterine perfusion and cardiovascular variability demonstrates the best current prediction several weeks before clinical manifestation of PE.


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Paper Citation

in Harvard Style

Malberg H., Bauernschmitt R., Walther T., Voss A., Faber R., Stepan H. and Wessel N. (2008). ANALYSIS OF HEART RATE AND BLOOD PRESSURE VARIABILITY IN PREGNANCY - New Method for the Prediction of Preeclampsia . In Proceedings of the First International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2008) ISBN 978-989-8111-18-0, pages 47-55. DOI: 10.5220/0001066400470055

in Bibtex Style

author={H. Malberg and R. Bauernschmitt and T. Walther and A. Voss and Renaldo Faber and Holger Stepan and N. Wessel},
title={ANALYSIS OF HEART RATE AND BLOOD PRESSURE VARIABILITY IN PREGNANCY - New Method for the Prediction of Preeclampsia},
booktitle={Proceedings of the First International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2008)},

in EndNote Style

JO - Proceedings of the First International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2008)
SN - 978-989-8111-18-0
AU - Malberg H.
AU - Bauernschmitt R.
AU - Walther T.
AU - Voss A.
AU - Faber R.
AU - Stepan H.
AU - Wessel N.
PY - 2008
SP - 47
EP - 55
DO - 10.5220/0001066400470055