The Lingzhi Mushroom (Ganoderma lucidum) Extract Reduce the Number of Lymphocyte in Diabetics Rats with Periodontitis: In Vivo Experimental on Sprague dawley Rats

Pratitis Widi Seno, Amilia Ramadhani, Saryono, Haris Budi Widodo, Christiana C. Prihastuti

Abstract

Periodontitis is a chronic inflammation on the periodontal tissue that is characterized by attachment loss and bone loss. Diabetes mellitus deteriorated the condition of periodontitis. Ganoderma lucidum has the potential as anti-inflammation and anti-oxidant agents that can hasten the convalescence of periodontitis disease. This research aims to understand the effect of oral administration of Ganoderma lucidum extract on the number of lymphocytes in Sprague dawley rats induced with diabetes mellitus and periodontitis. The results showed that the estimated number of lymphocytes in groups that given the extract decreased as the doses increased. The group with 20 mg/kgBW dose has the lowest lymphocyte count and approached the healthy control group. The results of the Kruskal-Wallis test showed that there are significant differences among the five treatment groups for the estimation of lymphocyte counts (p <0.05). The Mann-Whitney test showed a significant difference between groups in estimating lymphocyte counts (p <0.05). This research concludes that there is an effect of G. lucidum extract to the amount of lymphocyte in Sprague dawley rats designed with diabetes mellitus and periodontitis.

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Paper Citation


in Harvard Style

Seno P., Ramadhani A., Saryono., Widodo H. and Prihastuti C. (2020). The Lingzhi Mushroom (Ganoderma lucidum) Extract Reduce the Number of Lymphocyte in Diabetics Rats with Periodontitis: In Vivo Experimental on Sprague dawley Rats.In Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC, ISBN 978-989-758-499-2, pages 254-259. DOI: 10.5220/0010490902540259


in Bibtex Style

@conference{jimc20,
author={Pratitis Widi Seno and Amilia Ramadhani and Saryono and Haris Budi Widodo and Christiana C. Prihastuti},
title={The Lingzhi Mushroom (Ganoderma lucidum) Extract Reduce the Number of Lymphocyte in Diabetics Rats with Periodontitis: In Vivo Experimental on Sprague dawley Rats},
booktitle={Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC,},
year={2020},
pages={254-259},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010490902540259},
isbn={978-989-758-499-2},
}


in EndNote Style

TY - CONF

JO - Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC,
TI - The Lingzhi Mushroom (Ganoderma lucidum) Extract Reduce the Number of Lymphocyte in Diabetics Rats with Periodontitis: In Vivo Experimental on Sprague dawley Rats
SN - 978-989-758-499-2
AU - Seno P.
AU - Ramadhani A.
AU - Saryono.
AU - Widodo H.
AU - Prihastuti C.
PY - 2020
SP - 254
EP - 259
DO - 10.5220/0010490902540259