Histopathology of Rat Kidney Organ Due to Ethanol Extract of Phaleria Macrocarpa Treatment Induced by Isoniazid

Ali Napiah Nasution, Sri Lestari R. Nasution

Abstract

The use of anti-tuberculosis drugs has side effects on human organs, especially the kidneys. Phaleria macrocarpa is now widely used as traditional medicine. The content of phaleria macrocarpa contains high antioxidants and this fruit is spread in North Sumatra. This study aims to determine the histopathological picture of induced kidney organ isoniazid (INH) by giving ethanol extract of phaleria macrocarpa. Animals test used in this study were 9 wistar rats which were divided into 3 treatment and experiments groups for 10 days. The results showed that the histopathology of kidney organ caused by INH were highly damage. However, giving Ethanol Extract of Phaleria macrocarpa at a dose of 3.4 g / 200 g was able to protect the kidneys (nephroprotector) from the toxicity of isoniazid drugs with minimal damage or almost normal. The administration of phaleria macrocarpa extract together with the anti-tuberculosis drug INH shows the protective effect of the kidneys against the INH drug

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Paper Citation


in Harvard Style

Nasution A. and R. Nasution S. (2020). Histopathology of Rat Kidney Organ Due to Ethanol Extract of Phaleria Macrocarpa Treatment Induced by Isoniazid.In Proceedings of the International Conference on Health Informatics, Medical, Biological Engineering, and Pharmaceutical - Volume 1: HIMBEP, ISBN 978-989-758-500-5, pages 243-247. DOI: 10.5220/0010296202430247


in Bibtex Style

@conference{himbep20,
author={Ali Napiah Nasution and Sri Lestari R. Nasution},
title={Histopathology of Rat Kidney Organ Due to Ethanol Extract of Phaleria Macrocarpa Treatment Induced by Isoniazid},
booktitle={Proceedings of the International Conference on Health Informatics, Medical, Biological Engineering, and Pharmaceutical - Volume 1: HIMBEP,},
year={2020},
pages={243-247},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010296202430247},
isbn={978-989-758-500-5},
}


in EndNote Style

TY - CONF

JO - Proceedings of the International Conference on Health Informatics, Medical, Biological Engineering, and Pharmaceutical - Volume 1: HIMBEP,
TI - Histopathology of Rat Kidney Organ Due to Ethanol Extract of Phaleria Macrocarpa Treatment Induced by Isoniazid
SN - 978-989-758-500-5
AU - Nasution A.
AU - R. Nasution S.
PY - 2020
SP - 243
EP - 247
DO - 10.5220/0010296202430247