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Authors: Tiro Setati 1 ; Willem Jacobus Perold 2 ; Pieter Rousseau Fourie 3 and Daniel Withey 4

Affiliations: 1 Council for Scientific and Industrial Research (CSIR), Pretoria, South Africa ; 2 Department of Electrical and Electronic Engineering, University of Stellenbosch, Stellenbosch, South Africa ; 3 innovation4life Intellectual Property (Pty) Ltd., Stellenbosch, South Africa ; 4 Council for Scientific and Industrial Research (CSIR) Pretoria, South Africa

Keyword(s): Control Systems, Model-Predictive Controller (MPC), Proportional-Integral-Derivative (PID) Controller, Anesthesia, Intravenous Infusion.

Abstract: Continuous intravenous drug delivery can require careful dosage and the maintenance of consistent blood plasma concentration levels. Here, the closed-loop control of drug concentration in simulated patients’ bloodstreams was investigated. During the investigation, the closed-loop controller performance of a Proportional-Integral-Derivative (PID) and a Model Predictive Controller (MPC) were compared. From the simulation results, the MPC has shown to be a better controller because of its shorter settling time and smaller stepresponse overshoot, which are desirable in a clinical setting. However, the MPC has shown to be more resource-intensive on the controller system. Through the simulations conducted, it can therefore be concluded that a closed-loop controller containing an MPC control block adequately controls the drug infusion to a simulated patient.

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Paper citation in several formats:
Setati, T.; Perold, W.; Fourie, P. and Withey, D. (2022). Comparing Closed-loop Control of Drug Infusion using MPC and PID. In Proceedings of the 15th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2022) - BIODEVICES; ISBN 978-989-758-552-4; ISSN 2184-4305, SciTePress, pages 126-133. DOI: 10.5220/0010783700003123

@conference{biodevices22,
author={Tiro Setati. and Willem Jacobus Perold. and Pieter Rousseau Fourie. and Daniel Withey.},
title={Comparing Closed-loop Control of Drug Infusion using MPC and PID},
booktitle={Proceedings of the 15th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2022) - BIODEVICES},
year={2022},
pages={126-133},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010783700003123},
isbn={978-989-758-552-4},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the 15th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2022) - BIODEVICES
TI - Comparing Closed-loop Control of Drug Infusion using MPC and PID
SN - 978-989-758-552-4
IS - 2184-4305
AU - Setati, T.
AU - Perold, W.
AU - Fourie, P.
AU - Withey, D.
PY - 2022
SP - 126
EP - 133
DO - 10.5220/0010783700003123
PB - SciTePress

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