Molecular Pathogenesis and Preventive Advances in HPV-Associated Cervical Carcinogenesis

Qila Sa

2025

Abstract

Cervical cancer poses a significant threat to women's health worldwide, with its pathogenesis being strongly associated with persistent infection by high-risk human papillomavirus (hrHPV). As the predominant oncogenic subtypes, HPV16 and HPV18 encode E6 and E7 proteins that disrupt cell cycle control through p53 degradation and pRb inactivation, drive genomic instability, and establish an immunosuppressive microenvironment to evade host immune surveillance. Prophylactic HPV vaccines (bivalent, quadrivalent, and nonavalent), utilizing virus-like particle (VLP) technology, effectively prevent targeted HPV infections and significantly reduce the incidence of premalignant lesions and invasive carcinomas. However, existing vaccines demonstrate limited efficacy in already infected individuals and against non-vaccine-targeted HPV types, while global disparities in vaccine accessibility and suboptimal vaccination coverage in males further compromise their preventive impact. Future directions should prioritize the development of pan-HPV spectrum vaccines, optimization of immunization protocols for high-risk populations, and breakthroughs in therapeutic vaccine design. Concerted efforts to ensure equitable vaccine allocation, implement male vaccination programs, and establish integrated prevention-screening-treatment frameworks will be crucial for accelerating the global elimination of cervical cancer. This review explores the evolving landscape of HPV vaccines, highlighting current challenges and emerging opportunities, aiming to inform evidence-based strategies for preventing and managing cervical cancer.

Paper Citation

in Harvard Style

Sa Q. (2025). Molecular Pathogenesis and Preventive Advances in HPV-Associated Cervical Carcinogenesis. In Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS; ISBN 978-989-758-789-4, SciTePress, pages 430-434. DOI: 10.5220/0014494700004933

in Bibtex Style

@conference{befs25,
author={Qila Sa},
title={Molecular Pathogenesis and Preventive Advances in HPV-Associated Cervical Carcinogenesis},
booktitle={Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS},
year={2025},
pages={430-434},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0014494700004933},
isbn={978-989-758-789-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS
TI - Molecular Pathogenesis and Preventive Advances in HPV-Associated Cervical Carcinogenesis
SN - 978-989-758-789-4
AU - Sa Q.
PY - 2025
SP - 430
EP - 434
DO - 10.5220/0014494700004933
PB - SciTePress