The Role and Clinical Significance of N6-Methyladenosine Methylation in Ovarian Cancer: Research Progress and Future Prospects

Xuanyi Dai

2025

Abstract

Ovarian cancer (OC), often diagnosed late due to asymptomatic early stages, remains highly lethal despite treatment advances. N6-methyladenosine (m6A) RNA methylation, regulated by writers, erasers, and readers, plays a key role in OC progression, metastasis, and chemoresistance by modulating RNA stability and translation. Dysregulated m6A modifications influence oncogenic pathways like PI3K/AKT and EMT, while m6A-related proteins serve as diagnostic and prognostic biomarkers. Preclinical studies highlight the therapeutic potential of targeting m6A regulators, though challenges like tumor heterogeneity hinder clinical translation. Future research should clarify m6A's roles, develop diagnostics, and advance m6A-targeted therapies. m6A methylation offers promising avenues for improving OC diagnosis, prognosis, and treatment.

Paper Citation

in Harvard Style

Dai X. (2025). The Role and Clinical Significance of N6-Methyladenosine Methylation in Ovarian Cancer: Research Progress and Future Prospects. In Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS; ISBN 978-989-758-789-4, SciTePress, pages 374-379. DOI: 10.5220/0014493600004933

in Bibtex Style

@conference{befs25,
author={Xuanyi Dai},
title={The Role and Clinical Significance of N6-Methyladenosine Methylation in Ovarian Cancer: Research Progress and Future Prospects},
booktitle={Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS},
year={2025},
pages={374-379},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0014493600004933},
isbn={978-989-758-789-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS
TI - The Role and Clinical Significance of N6-Methyladenosine Methylation in Ovarian Cancer: Research Progress and Future Prospects
SN - 978-989-758-789-4
AU - Dai X.
PY - 2025
SP - 374
EP - 379
DO - 10.5220/0014493600004933
PB - SciTePress