Application of Gene Editing Technologies in HIV Infection and Prevention

Zhihang Li, Haotian Luo

2025

Abstract

Human immunodeficiency virus (HIV) causes AIDS by interacting with host receptors like CD4, CCR5, and CXCR4. While antiretroviral therapies suppress viral replication, they don't provide a cure, and drug resistance is a persistent problem. Gene editing technologies, such as CRISPR-Cas9, TALEN, and artificial miRNAs, offer promising solutions for HIV prevention and treatment. By mimicking the CCR5Δ32 mutation, these technologies can block HIV entry into host cells. This review explores HIV infection mechanisms, the role of CCR5 in viral entry, and gene editing strategies to modify CCR5. It also examines animal models for cross-species infection and highlights successful HIV cure cases (the Berlin and London patients). The review provides insights into future gene editing strategies for HIV cure research, focusing on overcoming challenges and advancing treatment possibilities.

Paper Citation

in Harvard Style

Li Z. and Luo H. (2025). Application of Gene Editing Technologies in HIV Infection and Prevention. In Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS; ISBN 978-989-758-789-4, SciTePress, pages 340-344. DOI: 10.5220/0014488200004933

in Bibtex Style

@conference{befs25,
author={Zhihang Li and Haotian Luo},
title={Application of Gene Editing Technologies in HIV Infection and Prevention},
booktitle={Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS},
year={2025},
pages={340-344},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0014488200004933},
isbn={978-989-758-789-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS
TI - Application of Gene Editing Technologies in HIV Infection and Prevention
SN - 978-989-758-789-4
AU - Li Z.
AU - Luo H.
PY - 2025
SP - 340
EP - 344
DO - 10.5220/0014488200004933
PB - SciTePress