The Potential and Challenges of Circular RNA Vaccines: From Mechanism to Clinical Use

Yuling Song, Siyu Liu

2025

Abstract

Circular RNA (circRNA) is a stable, covalently closed RNA that regulates gene expression by sponging microRNAs and can sometimes translate into proteins. This makes circRNA a promising platform for vaccines against infectious diseases and cancer immunotherapy. Compared to mRNA vaccines, circRNA vaccines offer longer half-lives, enhanced stability, room-temperature storage, and reduced immunogenicity, minimizing adverse reactions and logistical challenges. However, key challenges include inefficient delivery, high production costs, and uncertain long-term safety. Ongoing research focuses on optimizing circRNA design, improving delivery methods (e.g., lipid nanoparticles), and developing cost-effective production techniques. This review discusses circRNA’s functions, its vaccine potential, and the obstacles to its clinical application in infectious disease prevention and cancer therapy.

Paper Citation

in Harvard Style

Song Y. and Liu S. (2025). The Potential and Challenges of Circular RNA Vaccines: From Mechanism to Clinical Use. In Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS; ISBN 978-989-758-789-4, SciTePress, pages 335-339. DOI: 10.5220/0014488100004933

in Bibtex Style

@conference{befs25,
author={Yuling Song and Siyu Liu},
title={The Potential and Challenges of Circular RNA Vaccines: From Mechanism to Clinical Use},
booktitle={Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS},
year={2025},
pages={335-339},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0014488100004933},
isbn={978-989-758-789-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS
TI - The Potential and Challenges of Circular RNA Vaccines: From Mechanism to Clinical Use
SN - 978-989-758-789-4
AU - Song Y.
AU - Liu S.
PY - 2025
SP - 335
EP - 339
DO - 10.5220/0014488100004933
PB - SciTePress