Rabies Virus Glycoprotein‑Based DNA Vaccines: Current Status and Future Directions

Yuqin Wang

2025

Abstract

Rabies is a very virulent viral infection, and rabies DNA vaccines are a novel approach to its prevention. These vaccines are prepared by placing the gene that codes for a key rabies virus antigen in a recombinant DNA plasmid under the control of eukaryotic ex-pression elements. When given to the body, they cause humoral and cell-mediated immune reactions with the following benefits: broad-spectrum immunity, long-term im-munity, fewer side - effects, easy production, and absence of requirements for cryopreservation. Nonetheless, DNA vaccines are limited by relatively weak immunogenicity relative to protein-based vaccines, uncertain long-term protection, and restricted mass production and regulatory approval. Ongoing research is aimed at enhancing immunogenicity, optimizing dosing regimens, simplifying production processes, and establishing appropriate regulatory infrastructures. These efforts will maximize the application of rabies DNA vaccines in rabies control globally.

Paper Citation

in Harvard Style

Wang Y. (2025). Rabies Virus Glycoprotein‑Based DNA Vaccines: Current Status and Future Directions. In Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS; ISBN 978-989-758-789-4, SciTePress, pages 330-334. DOI: 10.5220/0014488000004933

in Bibtex Style

@conference{befs25,
author={Yuqin Wang},
title={Rabies Virus Glycoprotein‑Based DNA Vaccines: Current Status and Future Directions},
booktitle={Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS},
year={2025},
pages={330-334},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0014488000004933},
isbn={978-989-758-789-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS
TI - Rabies Virus Glycoprotein‑Based DNA Vaccines: Current Status and Future Directions
SN - 978-989-758-789-4
AU - Wang Y.
PY - 2025
SP - 330
EP - 334
DO - 10.5220/0014488000004933
PB - SciTePress