The Role of Aberrant N6-Methyladenosine in Brain Disorders

Zhenqi Shi

2025

Abstract

N6-methyladenosine (m6A) methylation, the central eukaryotic RNA epigenetic modification, dynamically modulates RNA metabolism via the “writer-eraser-reader” network and influences neural development, synaptic plasticity, and brain disease progression. METTL3 suppresses Sox2 mRNA degradation during neural development to promote neuronal differentiation, while YTHDF2 mediates axon guidance gene degradation to modulate neural circuit assembly; YTHDF1-mediated local translation of synaptic proteins is learning and memory dependent. In illness, m6A imbalance is the basis of pathogenic mechanisms in Alzheimer's disease, glioblastoma, and traumatic brain injury. m6A regulatory components are potential prospects in preclinical models, but more investigations are desirable into multi-modification interaction machinery and tool development.

Paper Citation

in Harvard Style

Shi Z. (2025). The Role of Aberrant N6-Methyladenosine in Brain Disorders. In Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS; ISBN 978-989-758-789-4, SciTePress, pages 301-306. DOI: 10.5220/0014487100004933

in Bibtex Style

@conference{befs25,
author={Zhenqi Shi},
title={The Role of Aberrant N6-Methyladenosine in Brain Disorders},
booktitle={Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS},
year={2025},
pages={301-306},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0014487100004933},
isbn={978-989-758-789-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS
TI - The Role of Aberrant N6-Methyladenosine in Brain Disorders
SN - 978-989-758-789-4
AU - Shi Z.
PY - 2025
SP - 301
EP - 306
DO - 10.5220/0014487100004933
PB - SciTePress