The Emerging Roles of N6-Methyladenosine Modification in Hepatocellular Carcinoma

Ruibo Liu

2025

Abstract

In terms of cancer-related deaths, hepatocellular carcinoma (HCC) ranks high on a global scale. The molecular processes that cause HCC are still a mystery, even though many treatments have been developed for the disease in recent years. In mammals, N6-methyladenosine (m6A) methylation is one of the most significant RNA modifications. It is thought to regulate RNA metabolism and gene expression. Numerous regulatory variables govern this procedure. Two examples are methylase and demethylase. ncRNA, including circular RNAs circRNAs, lncRNAs, and miRNAs, are important players in the development and spread of tumours. They also regulate mRNA production, epigenetic alterations, and other biological processes. The diverse roles of m6A regulators in HCC include ferroptosis and metabolic reprogramming. In addition, this review examines inhibitors that target m6A enzymes as potential therapeutic targets for HCC, along with the present research status of m6A gene editing methods.

Paper Citation

in Harvard Style

Liu R. (2025). The Emerging Roles of N6-Methyladenosine Modification in Hepatocellular Carcinoma. In Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS; ISBN 978-989-758-789-4, SciTePress, pages 261-266. DOI: 10.5220/0014486200004933

in Bibtex Style

@conference{befs25,
author={Ruibo Liu},
title={The Emerging Roles of N6-Methyladenosine Modification in Hepatocellular Carcinoma},
booktitle={Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS},
year={2025},
pages={261-266},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0014486200004933},
isbn={978-989-758-789-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS
TI - The Emerging Roles of N6-Methyladenosine Modification in Hepatocellular Carcinoma
SN - 978-989-758-789-4
AU - Liu R.
PY - 2025
SP - 261
EP - 266
DO - 10.5220/0014486200004933
PB - SciTePress