Research Progress on N6-Methyladenosine Editing in Cancer Therapy

Chengxuan Zhang

2025

Abstract

One of the most prevalent internal alterations on mRNAs in eukaryotes is N6-methyladenosine (m6A). By altering several facets of RNA metabolism, such as translation, splicing, nuclear export, stability, degradation, and microRNA processing, m6A alteration governs and modulates gene expression. Several proteins known as "writers," "erasers," and "readers" control m6A alterations. METTL3, METTL14, WTAP, RBM15/15B, VIRMA, and ZC3H13 are among the writers; FTO, ALKBH5, and ALKBH3 are among the erasers; and YTHDF1/2/3, YTHDC1/2, IGF2BP1/2/3, HNRNP, and eIF3 are among the readers. Cancer is a significant socioeconomic and public health concern of the twenty-first century, accounting for around 22.8% of non-communicable disease-related deaths worldwide. Nonetheless, the studies demonstrate that new cancer treatments may be developed by adjusting the amounts of m6A alterations in particular genes. In order to help researchers better comprehend the development, this review aims to provide an overview of the research on m6A editing in cancer therapy.

Paper Citation

in Harvard Style

Zhang C. (2025). Research Progress on N6-Methyladenosine Editing in Cancer Therapy. In Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS; ISBN 978-989-758-789-4, SciTePress, pages 229-233. DOI: 10.5220/0014465400004933

in Bibtex Style

@conference{befs25,
author={Chengxuan Zhang},
title={Research Progress on N6-Methyladenosine Editing in Cancer Therapy},
booktitle={Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS},
year={2025},
pages={229-233},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0014465400004933},
isbn={978-989-758-789-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS
TI - Research Progress on N6-Methyladenosine Editing in Cancer Therapy
SN - 978-989-758-789-4
AU - Zhang C.
PY - 2025
SP - 229
EP - 233
DO - 10.5220/0014465400004933
PB - SciTePress