Recent Advances in siRNA Delivery System and Drugs

Wenjie Huang, Yichen Wu

2025

Abstract

siRNA drugs are an emerging class of nucleic acid drugs that can treat many diseases at the genetic level, especially for rare diseases. siRNA has the characteristics of poor lipid solubility, high immunogenicity, poor stability, and difficulty in in vivo delivery, which makes the development of related drugs full of challenges. However, the continuous innovation of molecular modification methods and increasingly sophisticated delivery strategies have brought hope to the development of siRNA drugs. This article reviews the mechanism of action, modification, delivery technology, and research and development history of siRNA drugs, aiming to provide feasible research and development strategies for potential siRNA drugs and continuously expand the clinical application of siRNA drugs.

Paper Citation

in Harvard Style

Huang W. and Wu Y. (2025). Recent Advances in siRNA Delivery System and Drugs. In Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS; ISBN 978-989-758-789-4, SciTePress, pages 223-228. DOI: 10.5220/0014465100004933

in Bibtex Style

@conference{befs25,
author={Wenjie Huang and Yichen Wu},
title={Recent Advances in siRNA Delivery System and Drugs},
booktitle={Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS},
year={2025},
pages={223-228},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0014465100004933},
isbn={978-989-758-789-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS
TI - Recent Advances in siRNA Delivery System and Drugs
SN - 978-989-758-789-4
AU - Huang W.
AU - Wu Y.
PY - 2025
SP - 223
EP - 228
DO - 10.5220/0014465100004933
PB - SciTePress