Research Progress of mRNA Vaccines for Cancer Treatment

Yingying Chen

2025

Abstract

Cancer has a high mortality rate and a high recurrence and metastasis rate, making it one of the most threatening diseases to humans at present. Traditional cancer treatment methods all have limitations, so it is very necessary to explore new treatment strategies. mRNA vaccines have unique advantages in cancer treatment and have shown excellent therapeutic effects in previous experimental studies. According to the type of RNA used, mRNA vaccines can be divided into four categories. After the cancer mRNA vaccine enters the human body and reaches the target cells, the antigen proteins are translated through ribosomes in the cytoplasm, thereby stimulating the body's anti-cancer immune response. There are many delivery systems for mRNA vaccines, mainly including lipid-based mRNA delivery tools, polymeric nanoparticles, peptide-based nanoparticles, inorganic nanoparticles, and biogenic nanoparticles. Cancer mRNA vaccines can encode tumor-associated antigens (TAAs), tumor-specific antigens (TSAs), CRISPR-Cas9, tumor suppressor factors, cytokines, therapeutic antibodies, etc., each with different advantages and functions. In addition, there are significant differences among mRNA vaccines used for different cancer treatments. mRNA vaccines for cancer treatment still face many pain points, such as the difficulty in determining universal and effective target antigens. In the future, we can continuously optimize cancer mRNA vaccines for these pain points to make them better applied in cancer treatment.

Paper Citation

in Harvard Style

Chen Y. (2025). Research Progress of mRNA Vaccines for Cancer Treatment. In Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS; ISBN 978-989-758-789-4, SciTePress, pages 212-217. DOI: 10.5220/0014464800004933

in Bibtex Style

@conference{befs25,
author={Yingying Chen},
title={Research Progress of mRNA Vaccines for Cancer Treatment},
booktitle={Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS},
year={2025},
pages={212-217},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0014464800004933},
isbn={978-989-758-789-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS
TI - Research Progress of mRNA Vaccines for Cancer Treatment
SN - 978-989-758-789-4
AU - Chen Y.
PY - 2025
SP - 212
EP - 217
DO - 10.5220/0014464800004933
PB - SciTePress