The Role of miRNAs in the Treatment and Regulation of Gastrointestinal Tumors

Weixiao Yuan

2025

Abstract

MicroRNA (miRNA) is a class of endogenous non-coding small RNA molecules that regulate gene expression at the post-transcriptional level by partially complementary binding to the 3'untranslated region (3'UTR) of target mRNA. This review summarizes miRNA's biogenesis and regulatory mechanisms, detailing the entire process from transcription and processing to maturation and functional exertion within the cell. Studies have shown that miRNA plays a crucial role in cell development, differentiation, proliferation, apoptosis, disease occurrence, and immune regulation. The development and progression of gastrointestinal tumors is a complex, multifactorial, and multistage process involving genetic factors, environmental factors, lifestyle, microbial infections, and precancerous lesions. Tumor cells promote their growth, invasion, and metastasis through genetic mutations, clonal evolution, and dynamic changes in the tumor microenvironment. This paper further explores the regulatory role of miRNA in gastrointestinal tumors and finds that specific miRNAs (such as miR-221, miR-125b, miR-320a-3p, etc.) significantly affect the progression of gastrointestinal tumors by regulating cell proliferation, apoptosis, metastasis, and invasion. In addition, miRNA, due to its stability and ubiquity in various biological fluids, shows potential as a tumor biomarker for early diagnosis and monitoring of tumor progression. Meanwhile, miRNA further influences tumor growth and development by regulating cells and metabolites in the tumor microenvironment. miRNA has excellent potential for application in controlling and treating gastrointestinal tumors. With the continuous progress of research and technology, miRNA is expected to become an essential tool for diagnosing and treating gastrointestinal tumors, providing new strategies and hope for cancer patients.

Paper Citation

in Harvard Style

Yuan W. (2025). The Role of miRNAs in the Treatment and Regulation of Gastrointestinal Tumors. In Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS; ISBN 978-989-758-789-4, SciTePress, pages 207-211. DOI: 10.5220/0014464600004933

in Bibtex Style

@conference{befs25,
author={Weixiao Yuan},
title={The Role of miRNAs in the Treatment and Regulation of Gastrointestinal Tumors},
booktitle={Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS},
year={2025},
pages={207-211},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0014464600004933},
isbn={978-989-758-789-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS
TI - The Role of miRNAs in the Treatment and Regulation of Gastrointestinal Tumors
SN - 978-989-758-789-4
AU - Yuan W.
PY - 2025
SP - 207
EP - 211
DO - 10.5220/0014464600004933
PB - SciTePress