Research Progress of Drug Delivery System of Metal-Organic Framework Materials in Drug Release Mechanisms

Xuechun Wang

2025

Abstract

Metal-Organic framework materials (MOFs) are promising drug carriers due to their high specific surface area, tunable pore structure, efficient loading and controlled release of drugs and excellent biocompatibility. In recent years, their application in targeted therapy and controlled release has attracted much attention. In this paper, we systematically review the preparation of MOFs as drug delivery systems for drug loading and their drug release mechanisms, focusing on three release strategies: diffusion control, chemical bond breaking and framework structure change. It was shown that MOFs could realise precise drug release through pH response, redox triggering and environmental stimuli. MOFs could synergistically deliver antigens and adjuvants in vaccine carriers to significantly enhance immune response. Despite the significant advantages of MOFs in targeting and stability, their biodegradability and large-scale production still need to be further optimised. The study provides insights for designing intelligent drug delivery platforms and promotes MOF applications in biomedicine.

Paper Citation

in Harvard Style

Wang X. (2025). Research Progress of Drug Delivery System of Metal-Organic Framework Materials in Drug Release Mechanisms. In Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS; ISBN 978-989-758-789-4, SciTePress, pages 187-191. DOI: 10.5220/0014446100004933

in Bibtex Style

@conference{befs25,
author={Xuechun Wang},
title={Research Progress of Drug Delivery System of Metal-Organic Framework Materials in Drug Release Mechanisms},
booktitle={Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS},
year={2025},
pages={187-191},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0014446100004933},
isbn={978-989-758-789-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS
TI - Research Progress of Drug Delivery System of Metal-Organic Framework Materials in Drug Release Mechanisms
SN - 978-989-758-789-4
AU - Wang X.
PY - 2025
SP - 187
EP - 191
DO - 10.5220/0014446100004933
PB - SciTePress