The Role of PP2A in the Pathological Mechanisms of Alzheimer’s Disease and Advances in Its Therapeutic Applications

Ketong Qian

2025

Abstract

Alzheimer’s disease (AD), a neurodegenerative disorder of the central nervous system, has become a pressing global health concern. The increasing incidence of AD, driven by an aging population, imposes significant socioeconomic burdens. Despite decades of research, the exact etiology and molecular mechanisms of AD remain unclear, limiting the development of effective treatments. It regulates key processes such as cell cycle progression, apoptosis, and signal transduction. Recent studies highlight its crucial role in AD pathophysiology, particularly in tau dephosphorylation and Aβ metabolism. Dysfunctional PP2A activity has been implicated in tau hyperphosphorylation, a major contributor to neurofibrillary tangle formation, and in the dysregulation of Aβ clearance. Investigating the role of PP2A in AD pathogenesis provides valuable insights into disease mechanisms and potential therapeutic targets. This review discusses the structural and functional aspects of PP2A, its contribution to AD pathology, and emerging therapeutic strategies aimed at modulating PP2A activity. Understanding these aspects may lead to the development of innovative approaches for early diagnosis, precision medicine, and disease prevention, ultimately improving patient outcomes.

Paper Citation

in Harvard Style

Qian K. (2025). The Role of PP2A in the Pathological Mechanisms of Alzheimer’s Disease and Advances in Its Therapeutic Applications. In Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS; ISBN 978-989-758-789-4, SciTePress, pages 149-154. DOI: 10.5220/0014436900004933

in Bibtex Style

@conference{befs25,
author={Ketong Qian},
title={The Role of PP2A in the Pathological Mechanisms of Alzheimer’s Disease and Advances in Its Therapeutic Applications},
booktitle={Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS},
year={2025},
pages={149-154},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0014436900004933},
isbn={978-989-758-789-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS
TI - The Role of PP2A in the Pathological Mechanisms of Alzheimer’s Disease and Advances in Its Therapeutic Applications
SN - 978-989-758-789-4
AU - Qian K.
PY - 2025
SP - 149
EP - 154
DO - 10.5220/0014436900004933
PB - SciTePress