Epigenetics in Cancer: Mechanisms, Oncogenesis, and Therapeutic Potential

Shiyuan Huang

2025

Abstract

Epigenetics are able to influence gene expression without changing the nitrogenous base sequence of DNA. These modifications include DNA methylation, histone modifications, chromatin remodeling, and non-coding RNA regulation, which all contributes to cancer development. Abnormal epigenetic changes can lead to oncogene activation and tumor suppressor genes (TSGs) silencing, making epigenetics promising therapeutic targets. This review explores the mechanisms of these four epigenetic processes, their roles in carcinogenesis, and current strategies for epigenetic therapy. It highlights the importance of understanding these mechanisms to address challenges such as high toxicity and low specificity, and to advance precision medicine in cancer treatment.

Paper Citation

in Harvard Style

Huang S. (2025). Epigenetics in Cancer: Mechanisms, Oncogenesis, and Therapeutic Potential. In Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS; ISBN 978-989-758-789-4, SciTePress, pages 69-74. DOI: 10.5220/0014400300004933

in Bibtex Style

@conference{befs25,
author={Shiyuan Huang},
title={Epigenetics in Cancer: Mechanisms, Oncogenesis, and Therapeutic Potential},
booktitle={Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS},
year={2025},
pages={69-74},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0014400300004933},
isbn={978-989-758-789-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS
TI - Epigenetics in Cancer: Mechanisms, Oncogenesis, and Therapeutic Potential
SN - 978-989-758-789-4
AU - Huang S.
PY - 2025
SP - 69
EP - 74
DO - 10.5220/0014400300004933
PB - SciTePress