Application of CRISPR Technology in the Treatment of Diabetes

Rui Cai, Ming Cong, Yanzhi Liu, Chenyu Xue

2025

Abstract

The prevalence of diabetes is high worldwide (more than 800 million adults worldwide have diabetes). At present, CRISPR technology therapy is the best treatment effect and the most promising method. It can fundamentally solve the pathogenesis of diabetes by editing the WFS1 gene or knocking out the RNLS gene in pluripotent stem cells. This paper studies the causes of diabetes and proposes that CRISPR can realize the reversal of diabetes, which may have certain implications for the treatment of type 2 diabetes (T2D) and other diseases in the future. Noncoding genomic defects in diabetes are analyzed and CRISPER technology is used to reveal a diabetic regulatory circuit. Finally, the pathogenesis of T1D and T2D were analyzed, and new treatment strategies for type 1 and T2D were revealed, which provided references for future CRISPR application research in diabetes. However, there are still problems to be solved, such as technical research limitations, potential safety risks, and the balance between technical application and ethics. Future research can also focus on the combination of CRISPR and other emerging technologies (such as nanotechnology, gene therapy, etc).

Paper Citation

in Harvard Style

Cai R., Cong M., Liu Y. and Xue C. (2025). Application of CRISPR Technology in the Treatment of Diabetes. In Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS; ISBN 978-989-758-789-4, SciTePress, pages 64-68. DOI: 10.5220/0014399300004933

in Bibtex Style

@conference{befs25,
author={Rui Cai and Ming Cong and Yanzhi Liu and Chenyu Xue},
title={Application of CRISPR Technology in the Treatment of Diabetes},
booktitle={Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS},
year={2025},
pages={64-68},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0014399300004933},
isbn={978-989-758-789-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Biomedical Engineering and Food Science - Volume 1: BEFS
TI - Application of CRISPR Technology in the Treatment of Diabetes
SN - 978-989-758-789-4
AU - Cai R.
AU - Cong M.
AU - Liu Y.
AU - Xue C.
PY - 2025
SP - 64
EP - 68
DO - 10.5220/0014399300004933
PB - SciTePress