Cramer-Rao Bound for Dipole Source Localization in Infants Using Realistic Geometry

Aleksandar Jeremic, D. Nikolic, G. Djuricic, N. Milcanovic, Z. Jokovic

2024

Abstract

Source localization of electrical activity in newborn infants is important from two standpoints. From an academic standpoint such insights can enable better understanding of brain development and from clinical standpoint localization of electrical activity can identify regions of the brain with higher than usual activity and possibly improve possible treatment outcomes. The electrical activity and the corresponding electroencephalography (EEG) measurements are dependant on electrical properties of brain and skull tissue i.e. corresponding conductivities and geometry. In this paper we investigate effects of realistic geometry in newborn infants by accounting for soft spots (fontanels) that are present in newborn infants. These structures have larger conductivity than regular bone tissue and hence the estimation accuracy can potentially be improved by optimally positioning EEG sensors on the surface of the skull. We generate forward model using realistic geometry and finite-element model generated by COMSOL. We utilize simplified source model consisting of single dipole source and calculate corresponding Cramer-Rao bound as a function of source intensity and locations.

Paper Citation

in Harvard Style

Jeremic A., Nikolic D., Djuricic G., Milcanovic N. and Jokovic Z. (2024). Cramer-Rao Bound for Dipole Source Localization in Infants Using Realistic Geometry. In Proceedings of the 17th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIOSIGNALS; ISBN 978-989-758-688-0, SciTePress, pages 807-810. DOI: 10.5220/0012470200003657

in Bibtex Style

@conference{biosignals24,
author={Aleksandar Jeremic and D. Nikolic and G. Djuricic and N. Milcanovic and Z. Jokovic},
title={Cramer-Rao Bound for Dipole Source Localization in Infants Using Realistic Geometry},
booktitle={Proceedings of the 17th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIOSIGNALS},
year={2024},
pages={807-810},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0012470200003657},
isbn={978-989-758-688-0},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 17th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIOSIGNALS
TI - Cramer-Rao Bound for Dipole Source Localization in Infants Using Realistic Geometry
SN - 978-989-758-688-0
AU - Jeremic A.
AU - Nikolic D.
AU - Djuricic G.
AU - Milcanovic N.
AU - Jokovic Z.
PY - 2024
SP - 807
EP - 810
DO - 10.5220/0012470200003657
PB - SciTePress