Navigating the Cyp2 Gene Family Research Landscape: A Comprehensive Bibliometric Analysis

Kristiadi Priambodo, Jefman Efendi Marzuki HY, Risma Ikawaty, Baharuddin, Salsa Bella Destri Syafika

2023

Abstract

This study elucidates the role of the CYP2 gene family in the pharmacokinetics and pharmacodynamics of drugs. The variability in these genes significantly influences drug efficacy and individual response. With the increasing volume of scientific publications, a comprehensive understanding of the current research on the CYP2 gene family is crucial. Numerous studies have examined these genetic variations, yet a thorough assessment of this research landscape and the identification of unexplored areas are still needed. Through bibliometric analysis and global mapping, this study enables a more systematic interpretation of publication data, offering new insights. The aim is to perform scientific mapping and interpretation of the CYP2 gene family research corpus. Utilizing literature review methods and bibliometric analysis based on PRISMA guidelines, a search in the Scopus database with the keyword cyp2* yielded 11,867 articles. After cleaning and preparation, 9,439 articles remained for analysis. The results indicate a significant increase in CYP2 gene research, particularly between 2012-2023. Mapping reveals five main clusters, with CYP2E1 and CYP2D6 as the largest. CYP2C9 stands out for its polarization with three other clusters, indicating strong research collaboration. Identified strategic areas include opioids, atrial fibrillation, PCI, DNA methylation, hepatocellular carcinoma, and bile acid. Key genes in polymorphism studies include CYP2C19 and CYP2C8, while CYP2D6 is crucial in drug monitoring. This science mapping provides essential insights for research development in precision medicine.

Paper Citation

in Harvard Style

Priambodo K., HY J., Ikawaty R., Baharuddin. and Syafika S. (2023). Navigating the Cyp2 Gene Family Research Landscape: A Comprehensive Bibliometric Analysis. In Proceedings of the 1st International Conference on Medical Science and Health - Volume 1: ICOMESH; ISBN 978-989-758-740-5, SciTePress, pages 278-285. DOI: 10.5220/0013671400003873

in Bibtex Style

@conference{icomesh23,
author={Kristiadi Priambodo and Jefman Efendi Marzuki HY and Risma Ikawaty and Baharuddin and Salsa Bella Destri Syafika},
title={Navigating the Cyp2 Gene Family Research Landscape: A Comprehensive Bibliometric Analysis},
booktitle={Proceedings of the 1st International Conference on Medical Science and Health - Volume 1: ICOMESH},
year={2023},
pages={278-285},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0013671400003873},
isbn={978-989-758-740-5},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Medical Science and Health - Volume 1: ICOMESH
TI - Navigating the Cyp2 Gene Family Research Landscape: A Comprehensive Bibliometric Analysis
SN - 978-989-758-740-5
AU - Priambodo K.
AU - HY J.
AU - Ikawaty R.
AU - Baharuddin.
AU - Syafika S.
PY - 2023
SP - 278
EP - 285
DO - 10.5220/0013671400003873
PB - SciTePress