Restoring mGluR-LTD Failure with the Induction of Arc Protein in the CA1 Region of APP/PS1 Mice

Yansheng Zheng, Lumeng Sun

2022

Abstract

Alzheimer’s Disease (AD) has become a severe problem across the world. Besides the major two hypotheses (ß-amyloid protein and tau protein), recent studies have also found that metabotropic glutamate receptor 5- dependent LTD (mGluR-LTD) failure is also one significant symptom of AD in APP/PS1 mice (AD mice model). Suppression of the inhibitor of de novo protein synthesis during the mGluR-LTD has successfully reversed the mGluR-LTD failure. Arc protein is an essential protein that coordinates the mGluR, and the level of Arc protein in the CA1 region of APP/PS1 mice is reduced. Therefore, an experiment is designed to increase the Arc level in APP/PS1 exogenously and endogenously to restore the mGluR-LTD by measuring postsynaptic responses.

Paper Citation

in Harvard Style

Zheng Y. and Sun L. (2022). Restoring mGluR-LTD Failure with the Induction of Arc Protein in the CA1 Region of APP/PS1 Mice. In Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB, ISBN 978-989-758-595-1, pages 753-759. DOI: 10.5220/0011294500003443

in Bibtex Style

@conference{icbeb22,
author={Yansheng Zheng and Lumeng Sun},
title={Restoring mGluR-LTD Failure with the Induction of Arc Protein in the CA1 Region of APP/PS1 Mice},
booktitle={Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,},
year={2022},
pages={753-759},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011294500003443},
isbn={978-989-758-595-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,
TI - Restoring mGluR-LTD Failure with the Induction of Arc Protein in the CA1 Region of APP/PS1 Mice
SN - 978-989-758-595-1
AU - Zheng Y.
AU - Sun L.
PY - 2022
SP - 753
EP - 759
DO - 10.5220/0011294500003443