The Relation between Gingipain, TREM-2 and the Condition of Alzheimer’s Disease

Xiaolin Ding

2022

Abstract

P. gingivalis is a kind of bacterial that causes Periodontitis, and will secrete gingipain, which can help the P. gingivalis to colonize inside the host. It is proposed that the gingipain that is secreted by P. gingivalis will activate TREM-1, which induces the inflammation inside the brain. The inflammation inside the brain will cause the neurodegeneration and cognitive decline, which in a way worthen the AD. Thus, it can be concluded that TREM-1 and gingipain have influences on AD. Beyond this, we found that TREM-2 shares homology with TREM-1, and some studies shows that TREM-2 can help to against inflammatory. In this paper, we came up with a hypothesis that the activation of TREM-2 reduces the level of inflammation and protects neurons from degeneration, mainwhile, P. gingivalis colonizes in the brain and exacerbates features of AD via its gingipains.

Paper Citation

in Harvard Style

Ding X. (2022). The Relation between Gingipain, TREM-2 and the Condition of Alzheimer’s Disease. In Proceedings of the 1st International Conference on Health Big Data and Intelligent Healthcare - Volume 1: ICHIH, ISBN 978-989-758-596-8, pages 169-172. DOI: 10.5220/0011238900003438

in Bibtex Style

@conference{ichih22,
author={Xiaolin Ding},
title={The Relation between Gingipain, TREM-2 and the Condition of Alzheimer’s Disease},
booktitle={Proceedings of the 1st International Conference on Health Big Data and Intelligent Healthcare - Volume 1: ICHIH,},
year={2022},
pages={169-172},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011238900003438},
isbn={978-989-758-596-8},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Health Big Data and Intelligent Healthcare - Volume 1: ICHIH,
TI - The Relation between Gingipain, TREM-2 and the Condition of Alzheimer’s Disease
SN - 978-989-758-596-8
AU - Ding X.
PY - 2022
SP - 169
EP - 172
DO - 10.5220/0011238900003438