Comparing Closed-loop Control of Drug Infusion using MPC and PID

Tiro Setati, Willem Jacobus Perold, Pieter Rousseau Fourie, Daniel Withey

2022

Abstract

Continuous intravenous drug delivery can require careful dosage and the maintenance of consistent blood plasma concentration levels. Here, the closed-loop control of drug concentration in simulated patients’ bloodstreams was investigated. During the investigation, the closed-loop controller performance of a Proportional-Integral-Derivative (PID) and a Model Predictive Controller (MPC) were compared. From the simulation results, the MPC has shown to be a better controller because of its shorter settling time and smaller stepresponse overshoot, which are desirable in a clinical setting. However, the MPC has shown to be more resource-intensive on the controller system. Through the simulations conducted, it can therefore be concluded that a closed-loop controller containing an MPC control block adequately controls the drug infusion to a simulated patient.

Paper Citation

in Harvard Style

Setati T., Perold W., Fourie P. and Withey D. (2022). Comparing Closed-loop Control of Drug Infusion using MPC and PID. In Proceedings of the 15th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2022) - Volume 1: BIODEVICES; ISBN 978-989-758-552-4, SciTePress, pages 126-133. DOI: 10.5220/0010783700003123

in Bibtex Style

@conference{biodevices22,
author={Tiro Setati and Willem Jacobus Perold and Pieter Rousseau Fourie and Daniel Withey},
title={Comparing Closed-loop Control of Drug Infusion using MPC and PID},
booktitle={Proceedings of the 15th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2022) - Volume 1: BIODEVICES},
year={2022},
pages={126-133},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010783700003123},
isbn={978-989-758-552-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 15th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2022) - Volume 1: BIODEVICES
TI - Comparing Closed-loop Control of Drug Infusion using MPC and PID
SN - 978-989-758-552-4
AU - Setati T.
AU - Perold W.
AU - Fourie P.
AU - Withey D.
PY - 2022
SP - 126
EP - 133
DO - 10.5220/0010783700003123
PB - SciTePress