Correlateions between UBE2T Expression and Immune Infiltration in Different Cancers

Yunliang Yu, Ting Li

2021

Abstract

Ubiquitin-conjugating Enzyme E2T (UBE2T) has been implicated in the development of several cancers. However, the interaction of UBE2T and cancer immunity in many tumors remains uncertain. In this study, we looked at the clinicopathological importance of UBE2T in various malignancies, as well as the links between UBE2T and prognosis and tumor-infiltrating lymphocytes in a variety of cancers. The Gene Expression Profiling Interactive Analysis (GEPIA) and Tumor Immune Estimation Resource (TIMER) databases were used to extract UBE2T expression data. The Kaplan-Meier plotter and the GEPIA databases were used to evaluate the relationship between UBE2T expression and cancer patients’ clinical prognosis. TIMER was used to look for relationships between UBE2T expression levels and tumor-infiltrating cells as well as gene marker sets of immune infiltrates. The findings demonstrated that increased UBE2T expression was substantially related to poor overall survival in individuals with breast cancer or lung adenocarcinoma. In thymoma, stomach carcinoma, and ovarian cancer, patients with a higher UBE2T expression had a better prognosis than those with low expression. Furthermore, elevated UBE2T expression impacted the prognosis of lymphatic metastasis in individuals with breast, lung, and stomach cancer. There were clear positive or negative relationships between UBE2T expression and immune cell infiltration in lung, stomach, and thymoma cancers. Finally, UBE2T may be valued for its dual role in human malignancies because it may play a significant role in the recruitment and modulation of immune infiltrating cells in tumors.

Paper Citation

in Harvard Style

Yu Y. and Li T. (2021). Correlateions between UBE2T Expression and Immune Infiltration in Different Cancers. In Proceedings of the 2nd Conference on Artificial Intelligence and Healthcare - Volume 1: CAIH, ISBN 978-989-758-594-4, pages 333-338. DOI: 10.5220/0011368400003444

in Bibtex Style

@conference{caih21,
author={Yunliang Yu and Ting Li},
title={Correlateions between UBE2T Expression and Immune Infiltration in Different Cancers},
booktitle={Proceedings of the 2nd Conference on Artificial Intelligence and Healthcare - Volume 1: CAIH,},
year={2021},
pages={333-338},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011368400003444},
isbn={978-989-758-594-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd Conference on Artificial Intelligence and Healthcare - Volume 1: CAIH,
TI - Correlateions between UBE2T Expression and Immune Infiltration in Different Cancers
SN - 978-989-758-594-4
AU - Yu Y.
AU - Li T.
PY - 2021
SP - 333
EP - 338
DO - 10.5220/0011368400003444