Analysis on How CRISPR Technology Facilitates Anticancer Therapeutics

Sitian Wang

2021

Abstract

As a novel treatment modality, immunotherapy, based on the principle of boosting the antitumour response, help patients to fight against cancer. Out of many different types of immunotherapies, adoptive T cell therapy, characterized by enhancing immunity and specificity by ex vivo manipulation on patient-derived T cells, has aroused great attention of scholars, who expect to apply it to future cancer treatment. Several CAR-T therapies have been officially approved in clinical use. Nevertheless, post-transfer T cell exhaustion and immunosuppression within the tumour region still constitute the major technical limitations. As an indispensable gene-editing tool with strong capacity in both biomedical research and clinical fields, CRISPR technology has strong potentials in facilitating adoptive T cell therapies to overcome the current barriers through full gene knockout on the engineered T cells. In this paper, the clinical feasibility and future prospect of the combined use of CRISPR-Cas9 and adoptive T cell therapies are analyzed using two latest studies for discussion and comparison. The studies indicate that CRISPR-Cas9 has facilitated to increase T cell persistence and potency in TCR therapy and CAR-T therapy respectively with acceptable safety profile, and it has shed the light for clinical use of CRISPR-Cas9 to increase the therapeutic effectiveness of adoptive T cell therapy. Future investigations are still needed to further assess its clinical safety and to understand the underlying mechanism of how CRISPR-Cas9 helps to extend the survival and increase anti-tumour response of the T cells within the tumour region.

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Paper Citation


in Harvard Style

Wang S. (2021). Analysis on How CRISPR Technology Facilitates Anticancer Therapeutics. In Proceedings of the 2nd Conference on Artificial Intelligence and Healthcare - Volume 1: CAIH, ISBN 978-989-758-594-4, pages 128-133. DOI: 10.5220/0011197300003444


in Bibtex Style

@conference{caih21,
author={Sitian Wang},
title={Analysis on How CRISPR Technology Facilitates Anticancer Therapeutics},
booktitle={Proceedings of the 2nd Conference on Artificial Intelligence and Healthcare - Volume 1: CAIH,},
year={2021},
pages={128-133},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011197300003444},
isbn={978-989-758-594-4},
}


in EndNote Style

TY - CONF

JO - Proceedings of the 2nd Conference on Artificial Intelligence and Healthcare - Volume 1: CAIH,
TI - Analysis on How CRISPR Technology Facilitates Anticancer Therapeutics
SN - 978-989-758-594-4
AU - Wang S.
PY - 2021
SP - 128
EP - 133
DO - 10.5220/0011197300003444