Formulation and Antibacterial Activity Test of Emulgel Containing Citronella Oil (Cymbopogon Nardus L.) with Variaton of Gelling Agent Carbomer

Dian Ermawati, Raditya Weka Nugraheni, Nia Zuardina, Meillya Hayyu Saputri

2019

Abstract

Citronella oil is the most volatile oil against Propionibacterium acnes. An emulgel preparation is made on a carbomer base because it has better release properties of the active substance compared to other bases. The research purpose was to determine the emulgel variation with carbomer base 0.5%, 1.0%, and 1.5% containing 2% Citronella Oil (Cymbopogon nardus L.) on the physical, chemical characteristic and the inhibition of Propionibacterium acnes bacteria growth. Emulgel with carbomer base made 3 formulations, namely F1 (0.5%), F2 (1%), and F3 (1.5%) with citronella oil content of 2%. The physical characteristics of the organoleptic, viscosity, homogeneity, dispersal, emulsion type, pH and stability (real time and freeze thaw) tests were performed. Antibacterial testing using the Agar Well Diffusion method. The organoleptic tests on FI (0.5%), FII (1%), and FIII (1.5%) were soft, white and has lemongrass odor. The results of one way Anova statistic showed that there were not significantly different for pH, dispersion, stability (freeze thaw and real time). The viscosity test was significantly different. The diameter of the inhibition zone of each formula has a mean of formula 1 was 12.65 mm formula 2 was 11.58 mm, and formula 3 was 10.25 mm. The conclusion of this experimentally is the effect of variations in emulgel based on 0.5%, 1.0%, and 1.5% carbomers containing 2% Citronella Oil on the growth of Propionibacterium acnes bacteria has significant difference which means that increasing carbomer levels it can significantly reduce the zone of antibacterial inhibition.

Paper Citation

in Harvard Style

Ermawati D., Nugraheni R., Zuardina N. and Saputri M. (2019). Formulation and Antibacterial Activity Test of Emulgel Containing Citronella Oil (Cymbopogon Nardus L.) with Variaton of Gelling Agent Carbomer.In Proceedings of the 2nd Health Science International Conference - Volume 1: HSIC, ISBN 978-989-758-462-6, pages 223-227. DOI: 10.5220/0009130302230227

in Bibtex Style

@conference{hsic19,
author={Dian Ermawati and Raditya Weka Nugraheni and Nia Zuardina and Meillya Hayyu Saputri},
title={Formulation and Antibacterial Activity Test of Emulgel Containing Citronella Oil (Cymbopogon Nardus L.) with Variaton of Gelling Agent Carbomer},
booktitle={Proceedings of the 2nd Health Science International Conference - Volume 1: HSIC,},
year={2019},
pages={223-227},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009130302230227},
isbn={978-989-758-462-6},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd Health Science International Conference - Volume 1: HSIC,
TI - Formulation and Antibacterial Activity Test of Emulgel Containing Citronella Oil (Cymbopogon Nardus L.) with Variaton of Gelling Agent Carbomer
SN - 978-989-758-462-6
AU - Ermawati D.
AU - Nugraheni R.
AU - Zuardina N.
AU - Saputri M.
PY - 2019
SP - 223
EP - 227
DO - 10.5220/0009130302230227