The Effect of Ethanol Extract of Okra (Abelmoschus esculentus L.) Moench) on Tumor Growth in Breast Cancer Rats Model Induced by Benzo-a-Pyrene

Syarifah Riska Mela Putri, Salomo Hutahaean, Syafruddin Ilyas, Widya Syahfitri, Fitri Elizabeth

2019

Abstract

Okra plant (Abelmoschus esculentus L. Moench)) is known as a medicinal plant that is traditionally used in treating various diseases. This study aims to investigate the effect of ethanol extract of okra seed pods on the growth of tumors in the rat breast cancer model. The experiment was carried out using a completely randomized design, with 5 treatments and 6 replications. These treatments were: 2 control groups (K- = normal group; K+ = breast cancer rat model due to benzo-a-pyrene or BAP injection), and 3 extract groups (breast cancer model rats were given okra extract at dose of 150, 300, or 450 mg/kg BW (body weight), respectively). The results showed that tumor growth occurred slowly in the first 3 months, but after that, the growth accelerated marked by an increase in tumor weight and tumor diameter. The average tumor weight due to BAP induction was 0.6 g, administration of the extracts of doses of 150 and 300 mg/kg BW gave no significant effect (P>0.05), but unexpectedly in doses of 450 mg/kg BW the average weight was 4.5 g (P<0.05). There is an indication that high-dose extracts stimulate tumor growth. The number of blood vessels has the same pattern as tumor growth. In the group of rats which were induced by BAP the number of blood vessels was 6 per visual area, whereas in the extract group the number increased by 9 to 10 vessels. The result suggest that A. esculentus extract may have an angiogenic effect at high doses.

Paper Citation

in Harvard Style

Putri S., Hutahaean S., Ilyas S., Syahfitri W. and Elizabeth F. (2019). The Effect of Ethanol Extract of Okra (Abelmoschus esculentus L.) Moench) on Tumor Growth in Breast Cancer Rats Model Induced by Benzo-a-Pyrene. In Proceedings of the 1st International MIPAnet Conference on Science and Mathematics - Volume 1: IMC-SciMath, ISBN 978-989-758-556-2, pages 502-508. DOI: 10.5220/0010208200002775

in Bibtex Style

@conference{imc-scimath19,
author={Syarifah Riska Mela Putri and Salomo Hutahaean and Syafruddin Ilyas and Widya Syahfitri and Fitri Elizabeth},
title={The Effect of Ethanol Extract of Okra (Abelmoschus esculentus L.) Moench) on Tumor Growth in Breast Cancer Rats Model Induced by Benzo-a-Pyrene},
booktitle={Proceedings of the 1st International MIPAnet Conference on Science and Mathematics - Volume 1: IMC-SciMath,},
year={2019},
pages={502-508},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010208200002775},
isbn={978-989-758-556-2},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International MIPAnet Conference on Science and Mathematics - Volume 1: IMC-SciMath,
TI - The Effect of Ethanol Extract of Okra (Abelmoschus esculentus L.) Moench) on Tumor Growth in Breast Cancer Rats Model Induced by Benzo-a-Pyrene
SN - 978-989-758-556-2
AU - Putri S.
AU - Hutahaean S.
AU - Ilyas S.
AU - Syahfitri W.
AU - Elizabeth F.
PY - 2019
SP - 502
EP - 508
DO - 10.5220/0010208200002775