The Correlation of Initial CD4 Cell Count with Increased Alanine Aminotransferase in Patients with Human Immunodeficiency Virus Who Have Received Nevirapine

Abdur Rokhim, Usman Hadi, Erwin Astha Triyono

2017

Abstract

Nevirapine is one of the most widely used antiretroviral drugs in developing countries. One of the current concerns is the high risk of hepatotoxicity associated with the use of Nevirapine in about 6-30% of patients and is the cause of discontinuation of antiretroviral therapy in 2-10% of patients due to severe liver disorders characterized by increased alanine aminotransferase (ALT). Hepatotoxicity in people with Human Immunodeficiency Virus (HIV) can be caused by many factors. Two mechanisms of nevirapine hepatotoxicity have been proposed. One of mechanisms is the immune-mediated hypersensitivity reaction that induces hepatotoxicity reactions that are thought to be associated with early CD4 counts. The aim of this study was to determine the correlation between initial CD4 count and elevated ALT levels in people infected with HIV who have received nevirapine for 3 months. This study was cross-sectional observational analytic research of 30 HIV-infected patients receiving nevirapine treatment. Each patient was assessed for initial CD4 cell count and initial ALT levels before receiving nevirapine treatment. After 3 months of nevirapine treatment, ALT re-examination was performed to determine elevated alanine aminotransferase levels, then correlation analysis was performed using Spearman's test. Spearman's correlation test results found a negative correlation between initial CD4 count and elevated ALT levels but not was statistically significant (r = -0.107; p = 0.573). In the sub analysis, a positive correlation was found between initial ALT level and ALT level increase (r = 0.427; p = 0.019). Initial CD4 count was not correlated with elevated ALT levels in HIV-infected patients receiving Nevirapine-based ARVs.

Paper Citation

in Harvard Style

Rokhim A., Hadi U. and Astha Triyono E. (2017). The Correlation of Initial CD4 Cell Count with Increased Alanine Aminotransferase in Patients with Human Immunodeficiency Virus Who Have Received Nevirapine.In Proceedings of Surabaya International Physiology Seminar - Volume 1: SIPS, ISBN 978-989-758-340-7, pages 356-362. DOI: 10.5220/0007339103560362

in Bibtex Style

@conference{sips17,
author={Abdur Rokhim and Usman Hadi and Erwin Astha Triyono},
title={The Correlation of Initial CD4 Cell Count with Increased Alanine Aminotransferase in Patients with Human Immunodeficiency Virus Who Have Received Nevirapine},
booktitle={Proceedings of Surabaya International Physiology Seminar - Volume 1: SIPS,},
year={2017},
pages={356-362},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0007339103560362},
isbn={978-989-758-340-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of Surabaya International Physiology Seminar - Volume 1: SIPS,
TI - The Correlation of Initial CD4 Cell Count with Increased Alanine Aminotransferase in Patients with Human Immunodeficiency Virus Who Have Received Nevirapine
SN - 978-989-758-340-7
AU - Rokhim A.
AU - Hadi U.
AU - Astha Triyono E.
PY - 2017
SP - 356
EP - 362
DO - 10.5220/0007339103560362