New Simple Phenomenological Model for Laser Doppler Measurements of Blood Flow in Tissue

Denis Lapitan, Dmitry Rogatkin, Saydulla Persheyev, Andrey Rogatkin

2017

Abstract

Laser Doppler flowmetry (LDF) for measurements of tissue blood flow is well-known today. The basic theory of forming the registered optical signal in LDF is the model developed by R.Bonner and R. Nossal. However, claiming to be a detailed and comprehensive analysis of the interaction of light with tissues, it does not describe many phenomena. Multiple simplifications and assumptions in the model diminish the efforts on the analysis of peculiarities of light scattering inside the tissue, resulting in a very approximate output. In this our study, a qualitatively similar result was obtained with the use of more simple and general approach. It was shown, that the power spectra of analyzed signals in the form of the exponential decay, similar to a fractal noise (1/f noise), is a consequence mainly of the Maxwell’s distribution of moving particles’ velocities. Moreover, in contrast to the classic model, our model shows that the first moment of the frequency is linearly proportional not only to the velocity of red blood cells, but also is inversely proportional to the wavelength of illuminating radiation, that is more physically grounded.

References

  1. Bonner, R. and Nossal, R., 1981. Model for laser Doppler measurement of blood flow in tissue. Applied Optics, 20(12), 2097-2107.
  2. Born, M., Wolf, E., 1964. Principles of optics. Second ed. Pergamon press, Oxford-London-Edinburgh-Paris.
  3. Cummins, H.Z. and Swinney, H.L., 1970. Light Beating Spectroscopy. Progress in Optics, 8, 133-200.
  4. Dmitriev, M.A., Feducova, M.V., Rogatkin, D.A., 2004. On one simple backscattering task of the general light scattering theory. Proc. SPIE., 5475, 115-122.
  5. Hu, C. L., Lin, Z. S., Chen, Y. Y., Lin, Y. H., Li, M. L., 2013. Portable laser Doppler flowmeter for microcirculation detection. Biomedical Engineering Letters, 3(2), 109-114.
  6. Koelink, M.H., De Mul, F.F.M., Leerkotte, B., et al., 1994. Signal processing for a laser-Doppler blood perfusion meter. Signal processing, 38(2), 239-252.
  7. Lapitan, D.G., Rogatkin, D.A., 2016. Variable hyperemia of biological tissue as a noise source in the input optical signal of a medical laser Doppler flowmeter. J. Opt. Techn., 83(1), 36-42.
  8. Mizeva, I., Maria, C., Frick, P., Podtaev, S., Allen, J., 2015. Quantifying the correlation between photoplethysmography and laser Doppler flowmetry microvascular low-frequency oscillations. J. of Biomed. Optics, 20(3), 037007.
  9. Mizeva, I., Frick, P., Podtaev, S., 2016. Relationship of oscillating and average components of laser Doppler flowmetry signal. J. of Biomed. Optics, 21(8), 085002.
  10. Nilsson, G.E., Tenland, T., Oberg, P.A., 1980. A new instrument for continuous measurement of tissue blood flow by light beating spectroscopy. IEEE Transactions on Biomed. Engineering, 27(1), 12-19.
  11. Podtaev, S., Stepanov, R., Smirnova, E., Loran, E., 2015. Wavelet-analysis of skin temperature oscillations during local heating for revealing endothelial dysfunction. Microvascular research, 97, 109-114.
  12. Rajan, V., Varghese, B., Leeuwen, T., 2009. Review of methodological developments in laser Doppler flowmetry. Lasers Med Sci, 24, 269-283.
  13. Roustit, M., Cracowski, J., 2012. Non-invasive assessment of skin microvascular function in humans: an insight into methods. Microcirculation, 19(1), 47- 64.
  14. Shiryaev, A.N., 1996. Probability. Springer, New York.
Download


Paper Citation


in Harvard Style

Lapitan D., Rogatkin D., Persheyev S. and Rogatkin A. (2017). New Simple Phenomenological Model for Laser Doppler Measurements of Blood Flow in Tissue . In Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2017) ISBN 978-989-758-216-5, pages 98-103. DOI: 10.5220/0006113200980103


in Bibtex Style

@conference{biodevices17,
author={Denis Lapitan and Dmitry Rogatkin and Saydulla Persheyev and Andrey Rogatkin},
title={New Simple Phenomenological Model for Laser Doppler Measurements of Blood Flow in Tissue},
booktitle={Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2017)},
year={2017},
pages={98-103},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0006113200980103},
isbn={978-989-758-216-5},
}


in EndNote Style

TY - CONF
JO - Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2017)
TI - New Simple Phenomenological Model for Laser Doppler Measurements of Blood Flow in Tissue
SN - 978-989-758-216-5
AU - Lapitan D.
AU - Rogatkin D.
AU - Persheyev S.
AU - Rogatkin A.
PY - 2017
SP - 98
EP - 103
DO - 10.5220/0006113200980103