based on SOA definitions. We remind that in this 
architecture, core business capabilities are 
encapsulated within independent software services, 
and these services are leveraged by various front-end 
applications to fulfill business requirements. The 
main properties of this approach are the use of 
business-oriented services; message-based 
interactions with “gray box” implementations; 
communication over a network; platform neutrality; 
service description and discovery; and loose 
coupling between system components (Kawamoto & 
Lobach, 2007). This set of properties leads to a 
simpler approach to software design and 
implementation and to enhancing re-use of existing 
IT resources. What gives to the system the ability to 
adapt to changing business requirements in a 
flexible, agile manner; and the potential for 
significant cost saving. 
Lessons learned from countries’ pioneer for the 
e-Health implementation shows that interoperability 
is a critical and crucial aspect for any national (and 
international) program. Many researches are 
contributing to develop it, but data exchange 
between softwares and between systems (respecting 
international directive for data control) still is a big 
challenge. These lessons had been taken into 
account during the development of RESIST project. 
The key idea is to improve the life quality of patients 
in Luxembourg, proposing a dynamic, flexible and 
standardized infrastructure to integrate healthcare 
application. The Plug-and-Play middleware 
developed in TAPAS project seams to be a good 
option to reach the RESIST aims. Our contribution 
in short term is the specification of an architectural 
framework to cover the stakeholders’ necessities and 
the implementation of a top level in TAPAS 
middleware to adapt it to healthcare applications’ 
needs. A case study has been specified to implement 
home monitoring in cardiology’s departments. 
Current works targeting the identification of the 
requirements to create a Luxembourgish e-health 
environment. It deals with patient interests, 
caregivers’ capabilities, healthcare centers’ 
managements and governmental regulations and 
administration.  
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