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Authors: S. Pimenta 1 ; M. J. Maciel 1 ; A. Miranda 2 ; M. F. Cerqueira 3 ; P. Alpuim 3 and J. H. Correia 1

Affiliations: 1 CMEMS-UMinho, Department of Industrial Electronics, University of Minho, Guimarães, Portugal ; 2 ICVS, School of Medicine, University of Minho, ICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães, Portugal ; 3 International Iberian Nanotechnology Laboratory (INL), Braga, Portugal

Keyword(s): Raman Spectroscopy, ex-vivo Analysis, Normal vs Tumor Mammary Glands.

Abstract: This paper demonstrates the potential of Raman spectroscopy in the ex-vivo analysis of resected normal and tumor mammary mouse glands, using a commercial confocal Raman microscope. The Raman spectra were acquired with a 785 nm excitation laser at 40 mW and using an integration time of 2 s. The Raman spectra for normal and tumor mouse mammary glands are presented and compared with literature results. The Raman spectrum of normal mammary mouse gland is dominated by lipid signatures. On the other hand, the Raman spectrum of tumor mammary gland is dominated by DNA and protein signatures. The molecular information obtained by using Raman spectroscopy can be fundamental for a more precise and complete diagnosis of tumors, for intraoperative assessment of tumors margins during surgeries and for tumors grade classification.


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Paper citation in several formats:
Pimenta, S.; Maciel, M.; Miranda, A.; Cerqueira, M.; Alpuim, P. and Correia, J. (2020). Raman Spectroscopy for Tumor Diagnosis in Mammary Tissue. In Proceedings of the 8th International Conference on Photonics, Optics and Laser Technology - PHOTOPTICS; ISBN 978-989-758-401-5; ISSN 2184-4364, SciTePress, pages 131-134. DOI: 10.5220/0009093501310134

author={S. Pimenta. and M. J. Maciel. and A. Miranda. and M. F. Cerqueira. and P. Alpuim. and J. H. Correia.},
title={Raman Spectroscopy for Tumor Diagnosis in Mammary Tissue},
booktitle={Proceedings of the 8th International Conference on Photonics, Optics and Laser Technology - PHOTOPTICS},


JO - Proceedings of the 8th International Conference on Photonics, Optics and Laser Technology - PHOTOPTICS
TI - Raman Spectroscopy for Tumor Diagnosis in Mammary Tissue
SN - 978-989-758-401-5
IS - 2184-4364
AU - Pimenta, S.
AU - Maciel, M.
AU - Miranda, A.
AU - Cerqueira, M.
AU - Alpuim, P.
AU - Correia, J.
PY - 2020
SP - 131
EP - 134
DO - 10.5220/0009093501310134
PB - SciTePress