Is the Identification of SNP-miRNA Interactions Supporting the Prediction of Human Lymphocyte Transcriptional Radiation Responses?

Marzena Dolbniak; Joanna Zyla; Sylwia Kabacik; Grainne Manning; Christophe Badie; Ghazi Alsbeih; Joanna Polanska

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Paper

Is the Identification of SNP-miRNA Interactions Supporting the Prediction of Human Lymphocyte Transcriptional Radiation Responses?

Topics: Data Mining and Machine Learning; Genomics and Proteomics; Transcriptomics

In Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 0BIOSTEC, 243-250, 2015 , Lisbon, Portugal

Authors: Marzena Dolbniak ¹ ; Joanna Zyla ¹ ; Sylwia Kabacik ² ; Grainne Manning ² ; Christophe Badie ² ; Ghazi Alsbeih ³ and Joanna Polanska ¹

Affiliations: ¹ Silesian University of Technology, Poland ; ² Centre for Radiation and Chemical and Environmental Hazards, Saudi Arabia ; ³ King Faisal Specialist Hospital & Research Centre, Saudi Arabia

Keyword(s): GWAS, miRNA, Single Nucleotide Polymorphism, Radiosensitivity, Gene Expression, Radiation.

Related Ontology Subjects/Areas/Topics: Bioinformatics ; Biomedical Engineering ; Data Mining and Machine Learning ; Genomics and Proteomics ; Transcriptomics

Abstract: Genome-Wide Association Studies (GWAS) are of great importance in identifying the genetic variants associated with traits/diseases. Due to the high number of candidate SNPs some filtering techniques are necessary to be applied. The aim of the study was to develop the comprehensive approach allowing for detailed analysis of both SNP-gene and SNP-miRNA-gene relations. We elaborated and optimized the novel signal analysis pipeline improving significantly the results of the analysis on genotype-phenotype interplay. Direct links between genotype results and gene expression levels were enriched by detailed analysis of SNP-miRNA-gene interactions at both mature miRNA structure/seed region and target binding site level. The proposed technique was applied to the data on lymphocyte radiation response and increased by almost 100% number of potential functional SNPs.

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Paper citation in several formats:

Dolbniak, M.; Zyla, J.; Kabacik, S.; Manning, G.; Badie, C.; Alsbeih, G. and Polanska, J. (2015). Is the Identification of SNP-miRNA Interactions Supporting the Prediction of Human Lymphocyte Transcriptional Radiation Responses?. In Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms (BIOSTEC 2015) - BIOINFORMATICS; ISBN 978-989-758-070-3; ISSN 2184-4305, SciTePress, pages 243-250. DOI: 10.5220/0005286102430250

@conference{bioinformatics15,
author={Marzena Dolbniak. and Joanna Zyla. and Sylwia Kabacik. and Grainne Manning. and Christophe Badie. and Ghazi Alsbeih. and Joanna Polanska.},
title={Is the Identification of SNP-miRNA Interactions Supporting the Prediction of Human Lymphocyte Transcriptional Radiation Responses?},
booktitle={Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms (BIOSTEC 2015) - BIOINFORMATICS},
year={2015},
pages={243-250},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0005286102430250},
isbn={978-989-758-070-3},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms (BIOSTEC 2015) - BIOINFORMATICS
TI - Is the Identification of SNP-miRNA Interactions Supporting the Prediction of Human Lymphocyte Transcriptional Radiation Responses?
SN - 978-989-758-070-3
IS - 2184-4305
AU - Dolbniak, M.
AU - Zyla, J.
AU - Kabacik, S.
AU - Manning, G.
AU - Badie, C.
AU - Alsbeih, G.
AU - Polanska, J.
PY - 2015
SP - 243
EP - 250
DO - 10.5220/0005286102430250
PB - SciTePress