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Authors: Hiroaki Nagase and Eiji Iwase

Affiliation: Graduate School of Fundamental Science and Engineering, Waseda University, Ohkubo3-4-1, Shinjuku-ku, Tokyo, Japan

Keyword(s): Mechanobiology, Bending Stimulus, Torsion Stimulus, Micro-Electro-Mechanical Systems (MEMS).

Abstract: In this study, we proposed the design for microstructure which can apply bending or torsion stimulus to cell using an external magnetic field. First, we defined “ideal bending stimulus” and “ideal torsion stimulus” for cell on a microstructure. In order to apply ideal bending or torsion stimulus to cells, the thickness of the microstructure of cell-culturing region is important. We designed and microfabricated the microstructure which consists of a thin silicon beam as cell-culturing region and a ferromagnetic material, nickel film for magneto-active structure. Then, fabricated microstructures actuated by external magnetic field and deformation of the microstructures was measured. From the results of the measurements, we calculated radius of curvature and angle of torsion respectively and we confirmed the platform almost actuated in theory. Our design of the platform can contribute to applying new kinds of mechanical stimuli to cultured cells.

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Paper citation in several formats:
Nagase, H. and Iwase, E. (2019). Design of Microstructure for Stimulating Mechanical Torque to Cells. In Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2019) - BIODEVICES; ISBN 978-989-758-353-7; ISSN 2184-4305, SciTePress, pages 215-219. DOI: 10.5220/0007483802150219

@conference{biodevices19,
author={Hiroaki Nagase. and Eiji Iwase.},
title={Design of Microstructure for Stimulating Mechanical Torque to Cells},
booktitle={Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2019) - BIODEVICES},
year={2019},
pages={215-219},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0007483802150219},
isbn={978-989-758-353-7},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2019) - BIODEVICES
TI - Design of Microstructure for Stimulating Mechanical Torque to Cells
SN - 978-989-758-353-7
IS - 2184-4305
AU - Nagase, H.
AU - Iwase, E.
PY - 2019
SP - 215
EP - 219
DO - 10.5220/0007483802150219
PB - SciTePress

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