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Authors: Shigeharu Ishida ; Hideaki Umeyama ; Mitsuo Iwadate and Y-h. Taguchi

Affiliation: Chuo University, Japan

ISBN: 978-989-8565-35-8

Keyword(s): FAMS, Autoimmune Diseases, Structure Prediction, Drug Discovery.

Related Ontology Subjects/Areas/Topics: Bioinformatics ; Biomedical Engineering ; Pharmaceutical Applications ; Structural Bioinformatics

Abstract: Drug discovery for autoimmune diseases is recently recognized to be an important task. In this study, we try to perform structure prediction of proteins whose gene promoter regions were previously reported to be specifically methelysed or demethylased commonly for three autoimmune diseases, systemic lupus erythematosus, rheumatoid arthritis, and dermatomyositis. FAMS were employed for this purpose and we can predict three dimensional structure with significantly small enough P-values. Most of them are suggested to be self immunology related proteins and will be important drug target candidates. We also found some proteins which form complex with each other. The possibility of a new drug target, i.e., suppression of protein complex formation is suggested.

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Paper citation in several formats:
Ishida, S.; Umeyama, H.; Iwadate, M. and Taguchi, Y. (2013). Structure Prediction with FAMS for Proteins Screened Critically to Autoimmune Diseases based upon Bioinformatics.In Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2013) ISBN 978-989-8565-35-8, pages 261-267. DOI: 10.5220/0004188802610267

@conference{bioinformatics13,
author={Shigeharu Ishida. and Hideaki Umeyama. and Mitsuo Iwadate. and Y{-}h. Taguchi.},
title={Structure Prediction with FAMS for Proteins Screened Critically to Autoimmune Diseases based upon Bioinformatics},
booktitle={Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2013)},
year={2013},
pages={261-267},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004188802610267},
isbn={978-989-8565-35-8},
}

TY - CONF

JO - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2013)
TI - Structure Prediction with FAMS for Proteins Screened Critically to Autoimmune Diseases based upon Bioinformatics
SN - 978-989-8565-35-8
AU - Ishida, S.
AU - Umeyama, H.
AU - Iwadate, M.
AU - Taguchi, Y.
PY - 2013
SP - 261
EP - 267
DO - 10.5220/0004188802610267

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